Hi, I don't know the answer -- but since both CML and Gleevec toxicity produce anemia because of marrow suppression, maybe it's not possible to tell the difference. E.g., both would show a low reticulocyte count.
This full text paper on anemia from Gleevec https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.23879 shows that other signs such as red blood cell size can vary, so that doesn't seem to help. Sorry.
i was taking vytorin and plavix when i was told i have cll .
My mother has CLL and I don't recall that being a symptom of it.
I was diagnosed with CML and given Gleevec 400 ml. After taking gleevec for 2 weeks doctor took additional blood test. My WBC dropped from 36.5 to 7.1 and all other blood counts came down to normal range. I'm wondering if gleevec could give such fast hematological response or I was possibly misdiagnosed originally. I don't and didn't have any symptoms, my spleen and liver weren't enlarged, no enlarged lymph. Should I get second opinion asap? Please, help me.
t want to see me, that fever was not from gleevec, and that I needed to monitor myself by myself by simply taken ibuprofen. This is what I did all last week and only this Monday he did a blood work.
For now, what can I do to help my body to build my immune system back? Any vitamins? I'll appriciate any advice.
I was diagnosed last year and was immediatley put on gleevec 400mg/day.At my last consult my metabolic stats had risen,hence blood tests to determine if the gleevec is no longer working.I am still in firstphase and wonder what my options are if the gleevec is no longer an option.Amin pretty good form,just very tired and a lot of bone pain.
I am a 50 year old woman with CLL, diabetes and COPD., My CLL is considered indolent.Stage 1-2 . Over the last 5 months I have steadily developed increased pain and stiffness symetricly in my hips and elbows. Sometimes in my hands too. It has become debilitating. My RA level has come back very, very high. and I'm now on painkillers daily. Is this a sign my CLL is transforming into something more aggressive? Or a new thing ?
I have CML and was treated with Gleevec for 4 years and achieved remission. I have for the past several months been experiencing sudden onset of weakness which last for hours, to days. My blood pressure which has remained under control for several years with atenolol has been running 145/105 and higher for the past three to four months. I have a feeling of fullness in my stomach, and I have sporatic episodes of mild coughing, this occurs maybe once a week.
anyway, my RBC is always on the low side/WBC varies from low side to normal/ lymphocyte varies from low range to normal-last test was 4.3. and normal range is 12.4-40.1/albumin is always abnormal-low and neutrophil 44.9-normal range 46.9-79.6. I read about your father's passing-so sorry for your loss.
Thanks for your time!
I am 60 and was diagnosed with CLL last year. I've gone in four times for follow-up labs and am now on a yearly watch. It's running an indolent course, but I'm a little confused by some of the labs. My WBC has remained stable between 12-15, but each lab results shows a pattern of the Lymphocytes increasing from the each previous lab. ALC was at 5, but now is 9. The platelets have been trending down with each lab as well, but still in normal range. Was at 256, but now is 188.
Question concerns Merkel Cell Carcinoma and CLL. Patient is 63 yo male, dx'd with prostate cancer '95 and treated with seeds. PCa metastatic to bone in '99. PCa controlled with double dose Casodex. Patient dx'd with CLL '99-no treatment given. WBC mostly 35-45K asymptomatic except slow wound healing. Patient dx'd with Merkel Cell Carcinoma '07. Merkel cell treated unsuccessfully with chemo and successfully with radiation.
All but one of the patients had monoclonal B cells in their pre-CLL blood samples, and 41 out of 45 had monoclonal B cells show up on both blood tests -- so monoclonal B cells could be a marker of future CLL."
Note that is about CLL, not AML or CML.
"monoclonal" means they are genetically all the same, but not cancerous. You can think of that as a condition that *might* progress to leukemia.
My father has had CLL for many years and now my doctor is doing final blood test to confirm the disease and a CAT Scan. Since my father has this and now I do (I am 59 yrs) does this mean CLL is hereditary.
I was sort of taken by surprise, I thought my white cell count was off because I was under stress with a husband who has terminal bladder cancer and I have been tired and stressed.
Does this disease always progress slowly or does it depend on each person?
Hi, unfortunately with smudge cells and your other signs, the first thing to look into is CLL and other B-cell blood cancers. The high calcium suggests Multiple Myeloma, but then CLL can also cause high calcium.
It's important to remember that CLL usually has a very good survival rate.
You don't mention easy bruising, so maybe the marrow is still okay.
If your WBC and your number of smudge cells hasn't been rising, that should probably be a good sign.
Good luck to you.
When I discovered I had leukemia, I immediately got in to MD Anderson Cancer Center. They retested my bone marrow and blood and found that I did NOT have the Mantle Cell. I was very relieved. I am hoping this disease is indolent and not aggressive, but if it takes off, I know I am being treated at the best place in the country.
Thanks again.
I was diagnosed with CLL at 48 and am now 53. Have been in watch and wait mode these years....and my counts have been growing slowly and no concerns so far. At my last lab work though, my lymphocytes jumped from 74% of my wbc to 85%....a significant jump from all these years of creeping growth. I'm quite concerned.....I am not currently sick or fighting any infections......am I now at the point where I can expect things to start going downhill?
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