Topical depigmenting agents, such as hydroquinone (
HQ) either in over-the-counter (2%) or prescription (4%) strength.
HQ is a chemical that inhibits tyrosinase, an enzyme involved in the production of melanin.
Tretinoin, an acid that increases skin cell (keratinocyte) turnover. This treatment cannot be used during pregnancy.
Azelaic acid (20%), thought to decrease the activity of melanocytes.
Facial peel with alpha hydroxyacids or chemical peels with glycolic acid.