Currently DESCOVY 25mg TAF plus 200mg emtricitabine is alead approved for hiv in the USA and canada. It could well be used for hbv, most likely at 1/2 tablet a day for hbv for patients who do not tolerate viread.
the emtricitabine. ..also called FTC, is also used in TRUVADA at the same dose, which is frequently used by hepatologists for patients with a suboptimal response to viread.
An international study found the antiviral combination of tenofovir and emtricitabine (Truvada) was most effective in treating younger adult hepatitis B patients with high viral load and normal ALT levels.
Doctors historically have not treated this group because there appeared to be no sign of liver damage. However, doctors now know that high viral loads may increase patients’ risk of liver damage and cancer as they age, despite their normal ALT levels.
the explanation of why tenofovir is so potent on hbv and makes no resistance was explained by the intracellular levels reached by this drug, it is so bad no study ever showed how all other nucs are extremely poor at this and when i found this comparison i was very very surprised
all ohter drugs are so weak as intracellular levels, just look at lam vs tdf.we dont have etv here but it is probably very poor too.
hbvdna intrahepatic needs to be suppressed as much as possible and hbvdna in serum undetactable to rescue some immune response so that peginterferon response is 90% or higher
monotherapies are all a failure, they are not a hbv cure and they just stop liver damage by lowering hbv replication
How do you differentiate an infected patient from an immunised client serologically
hbsab>10miu/ml only, immune by vaccine
hbsab>10miu/ml with hbcab positive too, immune after hbv clearance
cronic i
truvada is just tenofovir+ftc, it is sueless on hbv unless non response to tenofovir, which is extremely rare
it adds toxicity and higher price because truvada patent is not expiring in 2014, no difference on hbsag.
instead of truvada it is best only for those non responding to combo tenofovir+lamivudine.
Being a HBV forum, most of us know very little about Truvada except that it is prescribed off-label for HBV by some doctors, and that it is recommended for HBV patients who develop resistance to Tenofovir.
So I cannot answer all your questions, especially about the safety of Truvada during pregnancy, however I am sure you can find more information on that topics, especially from experiences of HIV mothers.
Due to the extremely low susceptibility to resistance and very low toxicity this drug became the cornerstone of antiviral treatment for HIV and HBV. It made Gilead Billions, of which Holy has seen a million a year grant for his Institute in Prague.
At the day he died, the FDA had approved Truvada, a combo of tenofovir and emtricitabine (FTC) (300/200mg) for use as a preventative in healthy individuals exposed to risk of infection.
Brief Intro: have been on Truvada for more than 3 years now, switching from LAM (lam resistance, I took lam for 3 years). HBeAg +, AntiHBe - , 25 years old, genotype B.
Ultrasound, fibroscan (around 5.0 kPa) & blood test (AST, ALT, Creatinin,... HBV DNA undetectable) every 6 months comes back normal (been doing this for 5 years now).
I'm thinking about taking Tenofovir only because I will move to a place where Emtricitabine is not available. I know it is better to combo.
t think, basing dosing on HIV folks is the right way to go for HBV treatment strategies. HBV and HIV do not even compare in terms of damage that HIV does to the whole body at once.
And they may as well have made an improvement to the drug. So I think it is a good thing if they keep the same potency at lower dose. Because it is very true that how much of it is absorbed by cells that is what really counts..
The following article maybe of interest to you. You really should talk with a HBV specialist before deciding on treatment.
Four-year Outcomes After Cessation of Tenofovir in Immune-tolerant Chronic Hepatitis B Patients
Article in Journal of Clinical Gastroenterology · July 2017
DOI: 10.1097/MCG.0000000000000852
Vincent Wai-Sun Wong
1st Vincent Wai-Sun Wong
49.77 · The Chinese University of Hong Kong
Aric J. Hui
2nd Aric J. Hui
Grace Wong
3rd Grace Wong
47.
To evaluate amino acid changes within HBV pol/RT after up to 240 weeks of tenofovir disoproxil fumarate (TDF) treatment and determine their potential association with resistance to TDF. No TDF resistance has been detected through 192 weeks of TDF treatment. Methods: Patients in Studies GS-US-174-0102 (HBeAg-) and GS-US-174-0103 (HBeAg+) were randomized 2:1 to receive TDF or adefovir dipivoxil (ADV) for 48 weeks followed by open-label TDF.
I was also a reciever. After 40 hours I went to the first clinic and they gave me PEP (TenofovirDF, emtricitabine + lamivudine). The clinic looks very unprofessional, but it was my only chance. I didn't do any hiv or std test, a month before the exposure i had HIV test which was negative. After few days I had a mild sore throat, i still have it, i don't have fever, running nose, rash or anything else. My questions are..
combo have no effect on hbv but more toxicity on you, if you have no resistance mutations baseline go for tenofovir only or tenofovir plus lamivudine which are the less toxic/more potent and retry interferon in 3 years
What are my chances of getting infected. Another question was administered a PEP drug emtricitabine and tenofovir, can it prevent me from contracting HiV.
People with continued detectable HBV DNA while on tenofovir had the option of adding emtricitabine (Emtriva) at week 72 or later. Safety and efficacy were assessed every 3 months, resistance testing was performed annually, and DEXA bone mineral density scans were performed starting at year 4 of follow-up.
About 90% of participants completed the initial blinded 48-week phase and entered the open-label phase.
My doctor told me that the virus mutated, and resisted to Lamivudine. My HBV DNA at that time was 24 million copies. I also did a liver biopsy, and that came up with a stage 2 (I think I was told there were some visible scar on my liver)
Started treatment with Truvada 2 years ago, got undetectable HBV DNA within 5 months. Also, my abdominal ultrasound came normal. AST, ALT, AFP, CBC in range.
My recent labs came up as follow:
These labs were done outside of the U.S.
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