- Absorption, oral: time to peak concentration 7h
- Elimination half-life = 12 h
(It says also that in general it can be administered once daily because it has a 24 h effect.Why?)
- Can you give another example to clarify it better please?
- When it says divide in 2 doses , does it mean only in the morning and dinner? 3 doses (morning-lunch-dinner)?
Thank you for taking the time to answer!!
The adverse effects experienced are similar to those with use of adenosine. While adverse effects are less frequent with dipyridamole (47% of patients), they tend to be more serious than those associated with adenosine. The most common adverse effects of dipyridamole are chest pain (19%), headache (12%), and hypotension (4.6%). In addition, 12% of patients require aminophylline for reversal of adverse effects.
Persantine is dipyridamole, but you will have to get extended release tablets as the two asprin and dipyridamole should not be taken together. Don’t change the medications without discussing with your doctor. So, consult him and then decide.
Hope this helped and do keep us posted.
What is nonreversible apical inferior wall and what does it mean when they say no dipyridamole-induced reversible ischemia .there is mild defect in the apical inferior wall that is not reversible at rest.
While you are taking Aggrenox (aspirin/dipyridamole), you should avoid taking over-the-counter pain medicine, especially any other products containing aspirin or non-steroidal anti-inflammatory drugs (NSAIDs).
Also, Avoid alcohol, or drink a minimal amount, as the combination of Aggrenox and alcohol could cause stomach bleeding.
Some of the alternatives include aspirin, Clopidogrel (Plavix), ticlodipine (Ticlid), dipyridamole (Persantine). Another alternative is Heparin injection. Different situations require different levels of anticoagulation. It is important to discuss the best treatment option with a physician.
I suffered a mild stroke (blood clot) Consultant prescribed Clopidogrel but cannot tolerate side effects. Then consultant prescribed Dipyridamole. I cannot tolerate this either. Severe headache, vomiting and diarrhoea. Has anybody got a different medication they are on?
ECG last month showed SVES, RBBB. This week he has stress test with dipyridamole protocol, and injection of thallium-201. The result showed "evidence of mild, small to medium size, irreversible perfusion defect in the inferior/inferolateral wall (mid to basal level)." Could you explain what this means? Does he need to have surgery or pacemaker? thanks in advance for your help.
False negative imaging is especially common when exercise is submaximal or in dipyridamole/adenosine studies of patients with severe obstructions of all three major coronary vessels. False positive scanning may be caused by signal attenuation from an elevated left hemidiaphragm or from breast tissue. These artifactual defects can be identified by performing a gated perfusion study to assess regional wall motion.
Pharmacological stress Tc-99m MIBI scan was performed with Dipyridamole given at arate of 0.14 mg/Kg/min over 4 minutes followed by injection of radio tracer 6 minutes later.
Findings are: Peak stress images revealed hypoperfused infero-septal and apical segment, which showed reversal at rest.
Impression: Findings are consistent with infero-septal and apical reversible ischemia.
Thanks all!
I can't help out on the pharmacokinetics, but your reasoning is sound: it doesn't make sense to dose so that the drug runs out.
I'd query Schering-Plough as well as your hepatologist, if I were you.
Please give me a heads-up if you solve the riddle.
Hepatic Impairment
In volunteers with hepatic impairment (Child-Pugh Class A and B), sildenafil clearance was reduced, resulting in higher plasma exposure of sildenafil (47% for Cmax and 85% for AUC). The pharmacokinetics of sildenafil in patients with severely impaired hepatic function (Child-Pugh Class C) have not been studied. A starting dose of 25 mg should be considered in patients with any degree of hepatic impairment [see Dosage and Administration (2.5) and Clinical Pharmacology (12.3)].
It should not be used if you are taking anticoagulant medications, including warfarin, aspirin, aspirin-containing products, NSAIDs, or antiplatelet agents (eg, ticlopidine, clopidogrel, dipyridamole). I am not sure of what other potential drug interactions.
I would discuss the use of this drug with your urologist and you should mention it whenever a healthcare professional inquires about the medications you are taking.
I looked at the package and ASASANTIN is a brand name for DIPYRIDAMOLE/ASPIRIN.
Thought I would clarify that.
Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..."
It however says that initiation of Folic acid and phenytoin together is beneficial.
Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.
The Phase 1 trial was designed to characterize the safety profile of ARC-520 across a range of doses and evaluate pharmacokinetics. It is a single-center, randomized, double-blind, placebo-controlled, single dose-escalation, first-in-human study of ARC-520 administered intravenously to healthy adult volunteers. All subjects have been dosed and received either placebo or ARC-520 in doses ranging from 0.01 mg/kg to 2 mg/kg.
i believe in the pre-clinical trials with healthy volunteers, researchers used Carbon14 to gauge the half-life and paths of elimination during pharmacokinetics studies. it is a common practice. perhaps that is what you are thinking about?
Other SSRIs, SNRIs, MAOIs, serotogenic drugs, NSAIDs, alcohol, tryptophan, aspirin, warfarin, clopidogrel, ticlopidine, dipyridamole, TCAs, phenothiazines, thioxanthines, butyrophenones, mefloquine, bupropion, tramadol, desipramine, clomipramine, nortriptyline, risperidone, thioridazine, haloperidol, flucainamide, propafenone, metoprolol, carbamazepine, ketoconazole, omeprazole, esomeprazole, fluoxetine, fluvoxamine, lansoprazole, ticlopidine, cimetidine, digoxin & other CNS drugs.
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