Desmopressin pharmacokinetics
Common Questions and Answers about Desmopressin pharmacokinetics
ddavp
My father had a brain tumor removed and now has to take a nasal spray called Desmopressin. His endocranologist only wants him to use it one time a day, but the problem is he goes to the bathroom sometimes every 15 minutes!!!! He is also on 1/2 mg of Dexamethasone and that's part of the problem. Sometimes he takes two puffs a day but the doctor doesn't want him to do that daily.
There is a drug called Desmopressin (DDAVP) it reduces urine production at night. But drinking too much liquid with the medication can cause problems, and Desmopressin should be avoided if you have symptoms such as a fever, diarrhea or nausea. Be sure to carefully follow instructions for using this drug.
Desmopressin is given orally as a tablet and is only for patients over 5 years old.
- Absorption, oral: time to peak concentration 7h
- Elimination half-life = 12 h
(It says also that in general it can be administered once daily because it has a 24 h effect.Why?)
- Can you give another example to clarify it better please?
- When it says divide in 2 doses , does it mean only in the morning and dinner? 3 doses (morning-lunch-dinner)?
Thank you for taking the time to answer!!
t mention in your question what medication you were taking. Commonly central DI is treated with desmopressin. Desmopressin works by limiting the amount of water passed in the urine.
I don't know why you would suddenly notice a decrease in your symptoms after 34 years. I would recommend making an appointment with your regular doctor to see what might be causing this. Until you can be seen, it is important that you remain aware of your fluid intake and output.
talk to your doctor about desmopressin, it works.
today the consultant gave me tablets called desmopressin acetate. i understand they reduce urine amounts. will try but cant see them working well.
Any new ideas or anyone with same prob please help.
Is there a medication for Diabetes Insipidus other than Desmopressin? The headaches as a side affect are dibilitating.
This discussion is related to <a href='/posts/show/557217'>peuatrygland diabetts</a>.
DDAVP, Stimate, Minirin) is a synthetic replacement for vasopressin, the hormone that reduces urine production. It may be taken nasally, or as a tablet. Lack of the hormone vasopressin is more common in men than in women. Typically, those that do not produce enough will "correct" by the end of puberty (19-25 years old for men). Check with your urologist about the possibility of this treatment. Best of luck.
If still the symptoms persist then medical treatment with desmopressin, imipramine and anticholinergics can be tried.
Hope it helps. Take care and please do keep me posted on how you are doing. Kind regards.
I can't help out on the pharmacokinetics, but your reasoning is sound: it doesn't make sense to dose so that the drug runs out.
I'd query Schering-Plough as well as your hepatologist, if I were you.
Please give me a heads-up if you solve the riddle.
5 hours before bedtime and was put on desmopressin .2mg nightly over the last year with no success. Her primary doctor added another medication and said to check back in 3 months. Her primary physician said that we should hold back on going to see a urologist. I was wondering if you can give me advise in what to do. HOW do you go about taking to your doctor and demanding a referral to a a specialist as a urologist with out being mean?
Hepatic Impairment
In volunteers with hepatic impairment (Child-Pugh Class A and B), sildenafil clearance was reduced, resulting in higher plasma exposure of sildenafil (47% for Cmax and 85% for AUC). The pharmacokinetics of sildenafil in patients with severely impaired hepatic function (Child-Pugh Class C) have not been studied. A starting dose of 25 mg should be considered in patients with any degree of hepatic impairment [see Dosage and Administration (2.5) and Clinical Pharmacology (12.3)].
I have seen urologists, done physical therapy, taken desmopressin, set alarms to wake up in the night, cut back my liquid intake in the evenings, had my bladder checked for abnormalities (there are none), used moisture-sensitive alarms, and attempted to train myself to make sure that I am fully awake when I get up in the night to urinate.
Sadly, none of these solutions have worked. People say that bedwetting is a problem that people grow out of, but I am starting to believe that I never will.
Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..."
It however says that initiation of Folic acid and phenytoin together is beneficial.
Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.
I too have DI but i take desmopressin and hydrocortizone daily. I found if I break the 20mg desmopressin into quarters I do better. The 5mg just didn't seem to work for me. I take it morning and night and other than a 10lb weight gain I have not had any side affects. If I don't take enough I feel fatigued and if I take to much my weight goes up but when the dose was decreased the bulk of the weight came off.
Have you tried other medications?
The Phase 1 trial was designed to characterize the safety profile of ARC-520 across a range of doses and evaluate pharmacokinetics. It is a single-center, randomized, double-blind, placebo-controlled, single dose-escalation, first-in-human study of ARC-520 administered intravenously to healthy adult volunteers. All subjects have been dosed and received either placebo or ARC-520 in doses ranging from 0.01 mg/kg to 2 mg/kg.
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