Hepatic Impairment
In a pharmacokinetic study of sixteen subjects with hepatic impairment (15 mild, 1 moderate per Child-Pugh score), both AUC and Cmax were approximately double the values seen in the healthy control group. Based on the findings, Cyclobenzaprine HCl should be used with caution in subjects with mild hepatic impairment starting with the 5 mg dose and titrating slowly upward.
He takes an aspirin a day as he was having recurrent TIAs and the risk on Coumadin was too great. He tried Plavix(was allergic) and Aggrenox which increased the headache frequency. We are just at a loss with his current neurologist and feel he is at a loss of what to do. We are seeing a new neurologist on Thursday with the hopes of finding something that will help.
55am, I forgot I took the celexa and I took Cyclobenzaprine. Do you think is something I should be worry? I looked online about the drug interaction and they say could be deadly. I am very worry. Any advice of what I can do? Do I gonna be okay? How long apart I can take those two medications?
Duke University Medical Center recommended the target range of 3.0 to 3.5 for the St Jude Medical leaflet valve. I have been on it since 1993. The instability has been only the last three years or so. Here's a link to a presentation that suggests vitamin K and the logic for doing so; http://www.dcpa.us/slides09/sun05.trujillo.vitk.
My father in law is an alcoholic who has Atrial Fibrillation and is on coumadin. His cardiologist will not perform a cardioversion for him until his INR is within an acceptable level but it never is! The coumadin nurses frequently tell him his levels are too high and tell him to not take any coumadin for days at a time then the cardiologist tells him his INR is top low and they post pone the cardioversion.
We usually admit the patients 3 days prior to the surgery when we withhold coumadin and start heparin once the INR is less than 2.0. After surgery we usually start the heparin 12 hours after the surgery and coumadin shortly thereafter. The patient usually don't leave the hospital until their INR above 2.0. These are not hard and fast rules, and some physicians are more careful than others.
The body has a hard time clotting the blood due to aging. Also, Coumadin is hard on the arteries and with her age her arteries may be weak or thin. Coumadin is a very strong blood thinner and has some very serious side effects such as stomach cancer. It also can cause osteoporosis. Before her doctor starts her on any blood thinner, make sure that she has blood drawn and it is proven that her blood is thick enough to require this. You also may want to seek a second opinion.
Hi. I am wanting to quit taking Cyclobenzaprine. I took 20mg a day off and on, like twice a week for 2 years, and then started taking the 20 mg every day for the last 13 years. I plan to wean off, and am wondering what to expect as of withdrawal symptoms. Also, does anyone know of a natural med I could take in it's place?
t do an ablation. I am now wearing and event monitor for 30 days. I have a feeling he wants me to go on coumadin. I don't want to do that because I am very active and I am petrified of bleeding out. when I went to my accupuncturist she said she believes it is happening because of the sympathetic nerve due to the stress I have been under. I also read where taking 40mg of vitaminB6 helps the arrhythmia. What are your thoughts on my situation.
She has really bad swelling in her legs, from the knees down, including her ankles and feet. Since her Coumadin dosage was doubled due to low INR levels about 6 months ago, the swelling has gotten worse. I understand that correlation is not causation, but is this common?
Also, do they ever decrease one's dosage of blood thinners, or is it always the other way around.
I have 2 artificial heart valves and am taking coumadin (target INR 2.5 - 3.5). I am living overseas and have very limited access to fresh/frozen fish. To help regulate my INR, I do have a portable tester that works well. I'm wondering if the blood thinning effects of fish oil (if any) will be measured by my INR testing machine. In other words, will the total blood thinning effects of both coumadin and the fish oil suppliments be measured by the INR?
You are right, certain medications particularly muscle relaxants and antichlinergics, interfere with the results of EMG like baclofen and flexeril or cyclobenzaprine that you are taking. It would be prudent to apprise your neurologist of all the medications you are on, so that the EMG results are appreciated in that light. Muscle biopsy can be taken up after an EMG. Consult your neurologist for his preferences and expertise. Take care.
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