Null Responder: A null responder is someone who achieves little or no decrease in hepatitis C viral load during HCV treatment.
http://www.thebody.com/content/art46371.html
So yes you should be treated as such, that said you are a eRVR which is great, hang in there and do the 48, i wouldn't quit with having that eRVR.
The study enrolled HCV genotype 1 patients who were prior null responders to treatment with interferon and ribavirin with METAVIR F0-F2 scores (cohort 1, n=80), or treatment-naïve patients and prior null responders with METAVIR F3-F4 scores (cohort 2, n=87).
supplements packaged under the label of ... Gary Null, a nationally prominent pitchman for homeopathic remedies. Null is suing the manufacturer who supplies the product on which Null affixes his Ultimate Power Meal label. (According to consumer advisers at Quackwatch.org, Null is "one of the nation's leading promoters of dubious treatment for serious disease.") [New York Daily News, 4-28-10]
http://newsoftheweird.com/archive/index.
Phase 3 REALIZE study that evaluated people with genotype 1 chronic hepatitis C whose prior treatment with pegylated-interferon and ribavirin was unsuccessful either because they relapsed, had a partial response or had a null response.
Excellent definition of null responders in your link:
"null responders defined as non-response week 4 (<1 log drop in HCV RNA at week 4) or as non-response week 12 (<2 log drop in HCV RNA by week 12)"
This is a question for those of you who follow and understand the trials so well. I can't seem to find the results for Boceprevir patients who were previous null-responders. I can find it for non-responders but not null. Do any of you know if they looked at that cohort of people who never had a 2 log drop and what their results were? Also did they look at stage 4 patients? Thanks.
I am asking because I am trying to figure out if I should go with boceprevir....
BOSTON — A phase 2b trial of an oral, interferon-free regimen of 3 direct-acting antiviral drugs (DAAs) has shown very good efficacy in the treatment of hepatitis C virus (HCV) infection in both treatment-naive patients and null responders.
The real test will be how these results look in non-responders, null responders, relapsers, partial responders, etc. Alot of these drugs do fantastic in the naive patients, but the typically these results aren't quite that high on a non-responder patient. Now, if it's still this high in a non-responder patient, I'd be the first one to say, 'give me that drug'!
news to come out of this meeting, needless to say, and the biggest advancement in medicine in 50 years. In this study 4/11 null-responders receiving BMS-790052 (NS5A inhibitor) + BMS-650032 (protease inhibitor) alone for 24 weeks achieved SVR12 & SVR24. The presentation says "HCV infection can be cured without interferon & ribavirin".
without referencing relapsers around 60% nonresponders around 40% theres also null responders partial responders and breakthrough
BUT I found out if you withhold information on a legal document knowingly then the document becomes null and void, meaning if the courts found out (if ur ex found out later and went to court or something) your dissolution of marriage would be null and your marriage reinstated, making any following engagements null and void instead and you would have to restart the process.
My father is a state rep and also practice family law for many years, and thats how i found all this out.
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