Liver Cancer Cells Coaxed To Commit Suicide By Common Anti-Inflammatory
The anti-inflammatory drug celecoxib, known by the brand name Celebrex, triggers liver cancer cell death by reacting with a protein in a way that makes those cells commit suicide, according to a new study.
Researchers also found that the combination of celecoxib with each of two chemotherapy drugs killed more liver cancer cells in culture, making those combinations more effective than either drug on its own.
About 2 weeks ago, I noticed small red spots appear on my inner thighs and feet and also hands. I started taking Vitamin-C for about 10-12 days and the spots are gone.
But recently, when I had bad sleeps I found blood in my nose when I woke up. And when I spit sputum in the sink there's some blood with it. and sometimes my nose bleeds all of sudden. It's easy to stop bleeding and it only lasts for like 1 minute or so.
PS. I take Celecoxib daily for my joint's pain.
We also observed the enhanced phosphorylation of Akt and its downstream substrates glycogen synthase kinase-3beta and proapoptotic Bad in the HCV replicon-expressing cells. These phosphorylation events were sensitive to inhibitors of Cox-2 (celecoxib and NS-398) and phosphatidylinositol 3-kinase (LY294002). Our results also suggest a potential role of Cox-2 and PGE(2) in HCV RNA replication.
I called my Pharmacist and found out that they had just switched my usual Celecoxib for a newer generic version of it and so I stopped taking that one and started taking my old one and stopped the Citalopram, Divalproex DR and Buspar and I am feeling much, much better . I am still having some dizziness but not near as bad as before. But it may be due to my having a Flare of Uveitis right now, too.
I have had gout in my right big toe sevral times but this time my ankle started hurting first and swelling and the next day my big toe started hurting I started taking naproxen 500mg two days went by and it was not doing the trick. I called my Doc. and he done some blood work he said that the uric acid was on the hi side of normal. He started me on Methypred this is my 2nd day of that. Can I take Naproxen with that are not? And can you get gout in both places at once?
What has helped me the most is Celebrex (celecoxib); It is an anti-inflammatory and unlike over the counter ibuprofen it is safer for your stomach. You want to target reducing inflammation, instead of killing the pain (such as with Narcotics). If you simply kill the pain, you will revert to habits like poor seating position or movement patterns that can exacerbate the injury -- deadly cycle. Ice does this, as well.
The same thing happened to me, Also have an allergy to Ibuprofen All of the Coxibs like celecoxib and even to ketarolac - as Dr_Veena said they do belong to NSAID group, however currently I'm very cautious in taking any drugs for headaches, different antipyretics like acetominophen and salicylates like aspirin.
So went to hospital a week ago and did x-ray and blood test. Doctor has given me Celecoxib 200 mg capsules twice a day for 14 days and a gel to apply on my shoulder. Few times when I'm out I missed applying the gel but never missed the capsules (although once I had the capsules 4 hours late).
Today I received the x-ray image and report by email, and still waiting for the blood test report.
She gave me Ethical ciprobiotic Uro, and an antiinflamitory; Celeco, celecoxib 400mg. 2 to 3 hours later I am now peeing alot of blood. How concerned should I be, becuase I feel slightly wonky and a little scared. I cant get ahold of my friend to take me to the hospital and cant go out alone now becuase its late. Is this normal to pee blood? Is this prescription to high for me?
Chances of allergy are high in your case as you got the symptoms after taking the drug and you were almost symptom free when you did not. Instead you can take COX-2 inhibitors like rofecoxib and celecoxib or nimesulide. Try local analgesic creams and sprays and hot water bags. These will be equally effective in relieving pain without loading your system with drugs.
Hope this helps. Please let me know if there is any thing else and do keep me posted. Take care!
• I feel pinches in my body especially in neck and arm, I checked with the doctor (without telling him about my exposure) and he told me that may be from Thyroid and he tested it and it is OK and then he told me that I may have anxiety.
• Do you think I am taking risk and bad decision to return back to unprotected sex with my wife?
I am thinking so much and over worry and I need to through this subject away from my life and look to my family.
I cant ly on my left side because of the pain and it feels that there is not enough space for my lung and my hart beat raises. My left arm also pain and have pins and needles in my hand. I also suffer from fever for years. Most days I am feeling sick. I do take Celebrex for the rib pain these last month. I were diagnosed yesterday with Cotsochondritis but do not know if it can be something else.
My 59 year old husband, Hep C+ diagnosed in 2007, F-4 Cirrhosis diagnosed in 2010, compensated liver (last blood work was in July, 2012, and he has never had ascites, varices, or hepatic encephalopathy), and failed three Hep C treatments in past 5 years (last failure was triple tx w/Incivek stopped treatment mid-April, 2012 due to viral breakthrough), not currently on treatment.
Question: He has had pain and selling on forearm recently.
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