I know this is 2014, five years after this post, but I have been on
Bystolic for several years as on
Metoprolol before which caused fatigue....I do not have the fatigue on Bystolic, but after taking for this many years have started having the weak, heavy leg thing, painful knees, had 15 lb. weight gain, and i only eat 2 healthy meals/day....now my B/P has skyrocketed with no changes in daily living....Dr. added Micartis.....