Deepending on how bad your GERD is, the combination is quite common. I take ranitidine and Dexilant (also a PPI). For
break through reflux, I take Mylanta or Rolaids. I have also been diagnosed with bile reflux and take a fourth medication for that.
It is best to manage GERD with diet and life style changes if you can. I also take a digestive enzyme and probiotic. I took a double dose of the probiotic for about 2 - 3 months a while back after taking a lot of antibiotics.