Ammonia toxicity tolerance and excretion

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ammonia

181575 tn?1250202386 The nucleoside/nucleotide agents have the advantages of oral administration, excellent tolerance, use in advanced liver disease, and high potency in lowering serum HBV DNA levels. The primary disadvantages of these agents are the need for long-term administration and variable rates of antiviral drug resistance. Oral drugs with a high genetic barrier to resistance and/or high potency (eg, entecavir or tenofovir) are generally preferred to reduce the likelihood of resistance.