Ammonia toxicity glutamine synthetase

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ammonia

Avatar m tn Formation of glutamine from glutamate, by glutamine synthetase, in the liver and brain is another means of detoxifying ammonia. Impaired liver function, shunting of blood around the liver, and increased muscle wasting all lead to increased serum ammonia levels in cirrhotic patients. Ammonia interferes with brain function at many sites. Ammonia crosses the blood-brain barrier and directly depresses the central nervous system.
Avatar m tn I'm more inclined to suspect that these findings are more likely related to metabolic toxicity/ammonia due to cirrhosis rather than viral infection or liver fibrosis, especially since the article did not point to similar findings in the pre-cirrhotic patients with liver disease. Just my 2 cents.