tysabri antibody assay

Food for thought for those on, or conteplating, Tysabri. Blood antibody testing for JCV may not be enough. http://www.medpagetoday.com/Neurology/MultipleSclerosis/39649?

The Risk of PML is greatest in the setting of a positive J-lymphocytesC virus, greater than 24 months of Tysabri, and concurrent use of other DMD's or steroids. Those are old recommendations, and new info will change them in the (near?) future. PML is caused by the J-C Virus. A little more than half of all people have been infected with the JC virus. It generally lives asymptomatically in the brain unless something has occurred to cause the immunity of the brain to be compromised.

I was offered Gilenya when I had problems with Tysabri (which turned out to be something other than Tysabri that caused it) and after reading the cardiac warnings and other side effects, chose not to take it. Tysabri has a wonderful financial support program. They fully donated my first 4 months of Tysabri until I could get an insurance program in place. Tysabri is considered an "outpatient" procedure and under my insurance, is paid for now at 100%.

I've been on Tysabri since 2012 and tested + before I started. Some months I feel better, some I don't.

(16) This rapid assay is based on electrochemiluminescence and is reported to reduce the window period by 5 days over antibody tests. A ninth, unidentified assay is a lineal immunoenzymatic assay evaluated to have a sensitivity of only 99.5% and a specificity of 94.8%.

HIV antibody test using Abbott Determine Recombigent Assay kit. They took blood form my nerve and gave the result in 4 hours time. I tried searching it on internet but couldnt find. I dont expect it to be better than a 2nd gen test as India is a scarce resource country. Any possible cause of ganglion type swelling in my forearm, It does not hurt, moves littlebit but can be felt by touching.

I have MS and Neuropathy. I am currently on Tysabri. Previously I was on Betaseron and IVIG. When I went to Tysabri my doctor took me off IVIG and now my Neuropathy is worse, my feet and legs are on fire. Does any one know if it is safe to be on Tysabri and IVIG at the same time? My doctor said she would need to consult with other doctors before she would add IVIG to my treatment.

I've been tested twice in the last year, and they were both negative. Since you can acquire JCV at any time, I opt to have my status tested once a year since I'm on Tysabri. There is also a Tysabri antibody titre available, now. I plan on doing that once a year, too, although development of Tysabri antibodies is relatively rare.

I have been hearing lots on this bored about this infusion thing w Tysabri. Since I am new at all this, I can't figure out exactly wat it is when I google it. Can someone please explain?? Very curious over here! Thanks!

(16) This rapid assay is based on electrochemiluminescence and is reported to reduce the window period by 5 days over antibody tests. A ninth, unidentified assay is a lineal immunoenzymatic assay evaluated to have a sensitivity of only 99.5% and a specificity of 94.8%.

9 (11/1000) Patients taking tysabri risk of PML with positive JC antibody and asecond risk factor (i.e. being on tysabri 24-48 months) 1/250 (4/1000) that does not mean you can not develope PML before the mmagic 24 mark. The risk just in creases at that point.

t know numbers yet, as nurse wants Neuro to tell me) There was apparently a note on my file that if it was positive that I was not to go on Tysabri. We never discussed this with her, and if the numbers are high of course I would not try it. , but, I know of people who are positive and low numbers and have done very well on Tysabri. I just want o give it a shot. I have to wait now till Wed. when my neuro is in and the nurse will chat with her as to what to do.

Hepatitis C antibody (Total) - Anti HCV Indeterminant HCV Abs - Tested by 2 different methods. Reactive in one assay but negative in second alternative assay. this may due to biological false positive reaction. if further clarification is required suggest Hep C RNA PCR qualitative/quantitative assay to confirm presence of virus/viral load. So I'm a bit confused. doctor explained that I may have HCV but she can't be sure before she does some more tests...

an HIV antibody/p24 antigen duo test at 4 or more weeks after exposure, or a stand-alone antibody test at 6 weeks. If I were in your situation, I would not feel a need for any further testing, but feel free if you remain nervous about it.

Now, based on the last MRI, he has officially diagnosed me and is recommending that I go on Tysabri infusions. From what I can tell on this forum, it seems like he's hitting an ant with a sledgehammer. It seems very unusual for people to be prescribed Tysabri right off the bat. I am very confused as to what drug to go on, if any. His first choice for me is Tysabri, followed by Gilenya, followed by Copoxone.

What that mean? Does it mean that those tests are unreliable?

They are essentially the same test........they just use different detection techniques. ICMA uses light to detect antibodies and antigens......which is why it's called immunochemiLUMINOMETRIC assay.

please explain results---- HSV IGM AB screen detected reference range not detected test name- herpes simplex virus IGM with reflex to titer herpes simplex antibody screen --detected out of range herpes simplex virus IGM antibody , titer 80H reference range <10 This test does not distinguish between HSV 1 and HSV 2 PR (DX) w/ refl titer and confirmatory testing- non reactive What does this mean in ordinary language?

There is an alogirthm for the chances of contracting PML while on tysabri. I believe it is on the tysabri website among other places. I will see if I can find it for you and report back.

Nonreactive results in this assay for individuals with prior exposure to HIV-1 and/or HIV-2 may be due to antigen and antibody levels below the limit of detection of this assay. UK testing guidelines. Post-test discussion The need for a repeat HIV test if still within the window period after a specific exposure should be discussed.

CSF - HSV 2 IGG ABS TO HERPES SIMPLEX VIRUS 2 Code: 9461CI Methodology: EIA REMARK : In order to achieve comparable relationship between CSF & Serum - 1. Pathogen Specific IgG in serum (dilution 1:404) & CSF (dilution 1:2) are run on CSF IgG HSV 2 kit separately(for which there are no established reference ranges) & CSF/serum IgG HSV 2 quotient calculated. 2. Total IgG in serum & CSF are run separately & CSF/serum Total IgG quotient calculated. 3.

Tysabri antibody assay

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