tysabri antibody test

I've been tested twice in the last year, and they were both negative. Since you can acquire JCV at any time, I opt to have my status tested once a year since I'm on Tysabri. There is also a Tysabri antibody titre available, now. I plan on doing that once a year, too, although development of Tysabri antibodies is relatively rare.

I had blood work done about 1 week before infusion #4 and found out last week that my tysabri antibodies test came back positive. Going tomorrow to see the dr for next step. Anyone have this experience of developing antibodies so quickly? What meds have been offered after tysabri?

I was offered Gilenya when I had problems with Tysabri (which turned out to be something other than Tysabri that caused it) and after reading the cardiac warnings and other side effects, chose not to take it. Tysabri has a wonderful financial support program. They fully donated my first 4 months of Tysabri until I could get an insurance program in place. Tysabri is considered an "outpatient" procedure and under my insurance, is paid for now at 100%.

-) It seems quite possible to have JCV DNA in your system but remain anti-body negative. In my last test, about 6 months ago, my blood antibody test came back positive, but my CSF remained negative. My Doc said it was OK to continue Tysabri for a wile. My inference was that JCV>PML does it's damage if it gets into your brain via CSF. I think that the bottom line is that you really can't rely on the old blood antibody test alone. You need to look deeper.

There is an alogirthm for the chances of contracting PML while on tysabri. I believe it is on the tysabri website among other places. I will see if I can find it for you and report back.

Good luck with Tysabri! I'm taking my 11th infusion on Wednesday. The good news, I haven't had any new flairs since I've been on it. I'm taking a "holiday" from Tysabri after this infusion. My neuro says a periodic holiday keeps the incidence of PML lower. I haven't had my JC virus antibody tested. Is this a blood test, or a urine test?

I have MS and Neuropathy. I am currently on Tysabri. Previously I was on Betaseron and IVIG. When I went to Tysabri my doctor took me off IVIG and now my Neuropathy is worse, my feet and legs are on fire. Does any one know if it is safe to be on Tysabri and IVIG at the same time? My doctor said she would need to consult with other doctors before she would add IVIG to my treatment.

I have been hearing lots on this bored about this infusion thing w Tysabri. Since I am new at all this, I can't figure out exactly wat it is when I google it. Can someone please explain?? Very curious over here! Thanks!

The Risk of PML is greatest in the setting of a positive J-lymphocytesC virus, greater than 24 months of Tysabri, and concurrent use of other DMD's or steroids. Those are old recommendations, and new info will change them in the (near?) future. PML is caused by the J-C Virus. A little more than half of all people have been infected with the JC virus. It generally lives asymptomatically in the brain unless something has occurred to cause the immunity of the brain to be compromised.

t know numbers yet, as nurse wants Neuro to tell me) There was apparently a note on my file that if it was positive that I was not to go on Tysabri. We never discussed this with her, and if the numbers are high of course I would not try it. , but, I know of people who are positive and low numbers and have done very well on Tysabri. I just want o give it a shot. I have to wait now till Wed. when my neuro is in and the nurse will chat with her as to what to do.

Hi. I'm a Tysabri user who thankfully has a negative JCV status. I'm on my 2nd year of this stuff, and I have no plans to stop anytime soon, because I haven't had a serious relapse since I've been on it (knock wood). I'll get my status tested once a year, and my neuro doesn't plan on more MRIs unless I change DMDs for some reason.

I had been on Tysabri for 22 month's and just recently stopped. I was wondering if any new info. is out there on the drug Rituxan for MS? I have SPMS with RRMS. I was in a study 3 yrs. ago at UCSF and did really well on Rituxan. However, Rituxan is not an approved drug for MS and at that time my insurance would not cover it so I had to discontinue taking it. Or should I just take a break for awhile and not take any ms med"s?

According to my neuro, some people have this side effect since the drug does esstenially attack the body and it is trying to defend itself. They even ran antibody tests to see if I was allergic to Tysabri due to my blood work. However, I was NOT tired all the time. The othrs may have a valid point in that it may just be MS related fatigue you are experiencing. Do tell them when you go for your next infusion about your symptoms. Please keep us informed about how things are going for you.

I'm looking forward to discussing Tecfidera with my doc later this month. My last JCV antibody test was positive so we're going to be looking for alternatives to Tysabri, my current DMD.

the big rush we get at ECTRIMS time with all these new thoughts and projects is always a thrill to me. I'm skimming through the releases, abstracts and poster presentations and finding lots of good stuff. I didn't see the correlation of the test between Tysabri and Tecfidera efficacy and will have to go back and read it in detail. I say we all go to ECTRIMS next year when it is in Boston....

HOWEVER if you continue to test negative for the JC Virus there is no reason you should have to stop tysabri if it is working for you. In fact, stopping Tysabri is shown to cause serious relapses and is not something fun to go through. I would talke to a different doctor about tysabri and get off the holiday idea. Of course if you test positive for the JC virus, that is a different story entirely. good luck in working this through with your medical provider.

Glad to hear that the 2nd infusion went well for you! it's great that you are able to get a nap while you are there, too... ;-) I've never fallen asleep during mine, but I do find it relatively relaxing - it's nice and quiet and peaceful, and I just usually bring something to read. I hope it all continues to go well for you on the Tysabri. I am still waiting to hear the results of my JC antibody test.

In the time I have been taking Tysabri, they have obtained much more data, as more and more people began taking Tysabri and staying on it longer. The JC virus test has been very helpful, allowing people who are negative to go on Tysabri with much less worry of PML, as well as giving people who test positive a better idea of the risks and allowing them to make more informed choices and decisions. At this time, they have identified 3 main risk factors for PML while on Tysabri: 1.

I am one of the older posters, and I am still on Tysabri. I just had #32. I had the JC virus test but still haven't gotten my results. Overall, my neuro and I both feel that Tysabri has helped slow down the parade of symptoms I was having, and that I'd be alot worse off right now if I wasn't on it. Feel free to PM me if you have any questions. ....

My new neuro suggested Tysabri based on increased lesions on Interferon (Rebif). Any persons out there on Tysabri that could share their experience?

I go for infusion #36 in a week or so, and so far so good. Still waiting to hear my JC virus antibody status. Did they test you for that? Hopefully the infusions will be as uneventful for you as they are for me.... :-) Keep us posted and let us know how it goes - PM me if there's any way I can help.

t feel like it did anything for me. I would like to go back on Tysabri. My test level is actually very low. Do you know how high the JC Virus level has to go to be high risk for PML to set in?

Tysabri antibody test

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