tysabri and steroids

of prednisone being ordered at the time of tysabri due to the action by way tysabri works, and the steriod combo. But, I have not read it. This is one of those things where a doctors orders are called for. Are you scheduled to start infusions?

Okay, I've had MS for 13 years. I was just taken off Tysabri in July, I was on that for almost 5 years. I now have to go on Gylena in January, but before I start the new drug...I have to do 6 months of iv steroids. 3 days every month with NO taper! I have just finished my second round...and I'm ready to through in the towel. The side affects of the steroids are at this point almost not worth doing. They are trying to prevent a relapse since I am not on any MS therapy.

I have been on Tysabri since February and also seem to crash the 4th week. It did get a bit easier as time went on and I felt such a difference on Tysabri for the better! The problem for me is that I seem to be very sensitive to the treatment and have had some fairly severe reactions during the infusion. There are times where I have only received 1/2 of the bag. I am premedicating very heavily now with Benydryl, etc and it seems to help.

Hi, Cammie, I failed Rebif after 2 back-to-back flairs. It also gave me hives. I started Tysabri in February, and had my 2nd infusion 2 weeks ago. I haven't noticed a big difference, yet. I have quite a bit of fallout from my last flair, namely, my inability to play my guitar for more than about 20 minutes. I've had to quit performing for the time being. I have a crazy strong immune system, and therefore not at huge risk for PML.

I went for my 6 month followup on copaxone and post dx. The good news is that the copaxone seems to be "doing its job" cause no new lesions. Bad news is that I was dx'd pretty advanced with a bunch of lesions. They told me the damage I already have isn't going away. The rheumatologist wants to figure out a drug that will cover both the lupus and the ms. My neuro started talking about tysabri. It scares the **** out of me. I just looked it up.

Hi Neena!!! Thanks for joining us :) I'm sorry you are having new worsening problems. Have you alerted your doctor? This may be a relapse for you and a course of steroids may help. Or, was the Tysabri suggested because the doc feels you may need a switch in meds? We do have Tysabri users on our forum, and I'll find a discussion about it and post the link here. It would be great if the Tysabri would indeed help you get some strength back.

You would not be on two DMDs at the same time, especially not with Tysabri. Previous DMD use has to be stopped and there is a washout period of at least 30 days before you can begin Tysabri. If the neurologist doesn't require a washout period, get out of there and go to someone who knows what they are doing. If you choose to go off of Tysabri, there is going to be another washout period. The recommended length for Tysabri to gilenya, is about 4 months.

So, new antibiotic, inhaler, nebulizer med, and STEROIDS. I am thinking about passing on the steroids, as it for make the Tysabri infusion another month out. We will see, although I couldn't have the Tysabri being sick either. I "might" call the neuro. As far as the knee, he is pretty sure the pain is from the bone spurs, which is caused by Arthritis, which progressed in my "good" leg, due to my gait from my "bad" leg.

With the steroids and Rebif I was able to move....transfer myself safely and use my walker inside for short distances. I did crash and burn when taken off the steroids but only back to where I was on my first visit to her. I am no worse off. So the DMD must have been preventing it from becoming worse. So, yes, I think they were helping. Guess I will just wait it out. I do think she understands insurance/Medicare and seems to be plowing ahead like it will happen.

Hello, I just finished #12 of tysabri. they did a 5 day infusion of Solmedrol,after that I noticed my scalp was itchy and I had little bumps ALL over my head. anybody else??? it is driving me CRAZY. IAM TO START a pill soon.

relapse activity and slowing of disability. I hope you do well on it. You definitely deserve a break!

That's horrible to live with that feeling! The burning parethesias can cause pure agony. I'm happy to hear that it has lessened for you. The ON I think I've had for a while but diagnosed only on Thursday. The doctor talked about putting a prism in my glasses to help correct the double vision. My pupils look much better today--only a slight difference (I no longer look like Cat Woman at least). My vision is about the same.

so we discussed copaxone and I am not thrilled at daily injections so we then discussed tysabri and feel that may be a good fit.

Welcome to the MS forum Jackie. Hoping I haven't done so, so you don't think I'm looney...lol So sorry the meds have failed you. I'm glad the steroids helped you and that they followed through w/checking your discs. They now should know that it's you MS and typical pain meds won't touch it. Some doctors do not recognize the pain associated with MS.

If my neuro and I decide to go the Tysabri route, I would stop the steroids. Too many risks involved with taking both. If I understand there will be a wait before they can start you on Tysabri so it might be smart to go ahead with the IVSM.

I just went to the neurologist yesterday and he didn't tell me anything good. I was diagnosed in August of this year and I have been on Copaxone for two months. I just recently started having tingling in my back and some numbness in my bottom lip. I thought I might be having another attack. The neurologist said he does think it's another attack and that it is probably effecting my brain stem because of my symptoms.

Last week I started my 3rd significant relapse this year, my specialist nurse is now talking about Tysabri. I was on Rebif for about 15 months and wasnt getting on with the side effects so I switched to Copaxone 6 weeks ago, which I'm quite happy with. I looked up Tysabri when I got home and all I got was all the bad news about the PML patients. They say that theres a 1/1000 chance of getting it, that seems quite high to me.

My neuro cancelled my upcoming infusion because of the steroids lousy timing going away end of may and no tysabri till June should be interesting.

s analysis of my symptoms, my exam and what his plan is; plus the bit on monthly steroids, and a little bit more on Vitamin D levels and supplementation. Elaine, has a lot more information on Vit D and levels and dose of supplementing. There are doctors who are recommending doses as high as 50,000 IU per day, but there is some real risk in this. Vitamin D toxicity can be life-threatening. The Vit D expert at OHSU feels that the upper safe limit for daily dose is 10,000IU.

Well, MS neuro called today, and said no more Tysabri. I have had 5 infusions so far, and unfortunately have been dealing with an awful vocal box issue(s). From having my immune system lowered, I developed a terrible problem with my vocal chords. It was so bad when they 1st looked, they had a hard time differentiating what was going on. There was thrush, ulcers. lesions and huge amounts of swelling. I have not had ANY voice for over 3 weeks! I was also not allowed to try to talk either.

So now he wants to take me off of the Copaxone, I have been on for a month and a half, and put me on Tysabri. I started the application process and now waiting for them to call me and get the ball rolling on that. Now he mentioned that this is the top of the line MS medication so that does give me some relief. P.S. I did test negetive for the JC Virus. Any thoughts, experiences etc on this Tysabri??!!

Tysabri and steroids

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