You are correct about there the MAJOR drug
interaction between tramadol and sertraline (
Zoloft). Please note that there are several moderate drug interactions with your medications, for example, sertraline (Zoloft), pregabalin (Lyrica), clonidine, and methocarbamol (Robaxin) all can increase side effects such dizziness, drowsiness, and impaired thinking and judgment when taken together. It would be a good idea to review your medication regimen with your provider and pharmacist.