Currently the recommended maximum
dose of 4g / day
, however, some US internists are now calling for a lower maximum
of 3g / day -- not because of hepatoxicity is found at 4,000mg, but because acetaminophen is included in so many OTC remedies for symptoms of colds and flu, sleep disturbance, allergy, and of course, pain, that many people are getting near or over the limit without realizing it.
In 2013 the FDA mandated changes in opioid formulations containing acetaminophen.