I had to quit Latuda because it made me manic- irritable, restless, agitated, racing thoughts, the whole bit. It started about 2 hours after I took the med. This is the number one reported side effect from it, although they call it "restlessness" and not mania. In my case, it was definately mania, not just physical restlessness.
I'm on Seroquel XR now which works great but I've gained 14 lbs. in 3 weeks.