Like other retinoids, it is a potent
teratogen following exposure in early pregnancy producing a variety of birth defects. When used topically, however, the risk is thought to be close to Zero. Elevated serum concentrations of all-trans reoinoic acid in early gestation are cnsidered teratogenic in humans. Because of its relatively poor systemic absorption after topical administration, however, use of the creams is not thought to present a significant fetal risk.