It is becoming more acceptable now that clopidogrel is a benefit for life. While aspirin works on one side of the clotting process, clopidogrel works from another. You say your heart attack was caused by cholesterol but this isn't strictly true. Cholesterol is one of the later processes which makes the heart attack happen but isn't the initial cause. The initial cause is damage to your artery linings which can be through blood pressure or bad diet.
I've lost count how many procedures I've had, but each has required the 600mg of clopidogrel. I too had problems with aspirin, so just stick with clopidogrel each day. I take 30mg of Lansoprazole each morning too. No stomach issues anymore. Clopidogrel has quite a short half life, so it will soon reduce back down in your body. I believe the half life is around 8 hours. So after 24 hours you will basically be back down to your usual level of 75mg.
What puzzles me is why a blood clot in arteries can be treated with aspirin/clopidogrel combine and the one in heart muscles will require warfarin? And why a blood clot should form on heart muscles which are dead for last six years?
I agree with you that even high dose of aspirin can cause bleeding. But over time I have got used to 150 mg of aspirin daily and psychologically my comfort level is higher.
Thankyou so much for sharing your thoughts.
Are we giving enough clopidogrel and aspirin to prevent stent thrombosis? And as we know, there are different levels of IPAs (inhibition of platelet aggregation). that has been measured with patients who are taking clopidogrel, and..."
There are studies about aspirin resistance and plavix resistance and there are studies that say it's 20-40% of the population. Other studies, at least with aspirin, it's about less than 1% if you use the arachidonic acid based (testing).
In the CAPRIE trial, clopidogrel (plavix) was equivalent to aspirin for patients with a recent (but not acute) MI. Some subgroups of patients with cardiovascular disease in this trial seemed to benefit more from clopidogrel than from aspirin: those with a history of bypass surgery, a prior stroke or MI, arterial disease in two or more areas, diabetes, or high cholesterol. Clopidogrel may be a reasonable choice for these patients.
If you’ve already had a heart attack or stroke or are resistant to the beneficial effects of aspirin, your doctor may suggest supplementary aspirin therapy with another clot-preventing drug, such as clopidogrel (Plavix). Clopidogrel may even be suggested as an alternative drug therapy, particularly if you’re allergic to aspirin or can’t tolerate its side effects."
Maybe someone will be able to add a thought or 2. Take care and keep us posted.
ve had arthralgia ,oseaophigitis,rashes and chest pain .
I was told there is no real evidence it reacts with clopidogrel (plavix) and if it does, the effect is tiny. My INR didn't change on this medication for 2 years. It would seem Aspirin is the culprit for causing my stomach issues, so I've been taken off aspirin and put back onto plavix for life.
If you are referring to Plavix (clopidogrel) and Aspirin, I would take them for life. The general rule used to be aspirin for life, plavix for a year. However, more and more cases of forming clots in stents were appearing when plavix was stopped, so now the general trend is changing towards life.
then dropped Plavix and continued with aspirin. There is some evidence that Plavix helps prevent restenosis with a drug eluding stent up to about a year.
There is a risk of excessive bleeding and that should be serious consideration when on anti-platelet medication, and the benefit, if any, don't outweigh the risk.
Hello; I have got one coronary DES stent implanted since two month ago ("Endeavor RESOLUTE RX"). I am on clopidogrel, aspirin, atorvastatin, carvedilol, enalapril and pantoprazol. Fearing about scars growing inside the stent's mesh, I have read that some people recommend vitamin E for cosmetic appearance of scars; well, my question is: Could vitamin E be of some help for preventing "in-stent restenosis"? Is it worth trying? Thanks!
In addition, I now follow the recently revised American Diabetes Association guidelines for aspirin use in people with diabetes. Whereas the ADA used to recommend low-dose aspirin for every diabetic patient over the age of 40, their new guidelines suggest aspirin as a prevention strategy only in those with diabetes whose cardiovascular risk is above average. This includes men over age 50 or women over age 60 with at least one additional major risk factor.
Some of the alternatives include aspirin, Clopidogrel (Plavix), ticlodipine (Ticlid), dipyridamole (Persantine). Another alternative is Heparin injection. Different situations require different levels of anticoagulation. It is important to discuss the best treatment option with a physician.
However, the dose needs to be adjusted well. Also aspirin can be combined with Coumadin. Aspirin can be combined with clopidogrel also and reduces the risk of stroke. Please discuss these options with her treating doctor. The risks of giving these in dialysis and HIV will have to be seen in light of risks involved with strokes.
Take care!
To make this work as a routine he now has to continue with the blood thinner CLOPIDOGREL along with his usual Aspirin daily. Also a daily walking for one hour. I am so grateful to the Doctor who made it possible for my husband to get relief from his Angina. My question to the people who are on the same boat.....
Do you get an awful bruising easily? Some bruising is common I heard but my worries are regarding cerebral haemorrhage.
Based on the level of risk, most patients are either started on aspirin or Warfarin (Coumadin). Clopidogrel (Plavix) is an anti-platelet agent and acts via a different mechanism than coumadin does (coagulation pathway). Adding Clopidogrel to aspirin is a guideline that holds a Class 2b (see below) recommendation, and usually considered in those in which Warfarin is unsuitable due to patient preference or physician's assessment on a patient's ability to safely sustain anticoagulation.
I take the generic Clopidogrel Bisulfate Tab 75. Had 3 stents in April 2009. I have to have dental work done. Deep cleaning and two fillings. My doctor said to go off medicine 3 to 5 days before procedure. Is this going to pose a risk?
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