Clopidogrel vs aspirin
Common Questions and Answers about Clopidogrel vs aspirin
plavix
After six years post MI and ef varying between 25-35%, my cardiologist now feels that I should shift from aspirin(150)+clopidogrel (75) to warfarin. Two years back he did tell me that he is double minded on whether to put me on warfarin. But this time he appears to be very sure and has insisted me to go for warfarin.
His justification is "that is what literature says".
I have no AF or valve problem.
Combining plavix and aspirin increases the risk of bleeding vs. aspirin alone in patients treated for more than a brief period of time. That is the regimen followed for my DES implant.
f you are in this category a prior MI and unstable angina:" In the CAPRIE trial, clopidogrel (plavix) was equivalent to aspirin for patients with a recent (but not acute) MI.
At 18-month follow-up, there was no difference between patients with a drug-eluting or bare-metal stent in cumulative rates of death or myocardial infarction (MI). However, after clopidogrel discontinuation patients receiving drug-eluting vs bare-metal stents experienced higher rates of death and MI (4.9% vs 1.3%, respectively). These results have created uncertainty regarding the minimal necessary duration of antiplatelet therapy after drug-eluting stent implantation.
It is becoming more acceptable now that clopidogrel is a benefit for life. While aspirin works on one side of the clotting process, clopidogrel works from another. You say your heart attack was caused by cholesterol but this isn't strictly true. Cholesterol is one of the later processes which makes the heart attack happen but isn't the initial cause. The initial cause is damage to your artery linings which can be through blood pressure or bad diet.
I've lost count how many procedures I've had, but each has required the 600mg of clopidogrel. I too had problems with aspirin, so just stick with clopidogrel each day. I take 30mg of Lansoprazole each morning too. No stomach issues anymore. Clopidogrel has quite a short half life, so it will soon reduce back down in your body. I believe the half life is around 8 hours. So after 24 hours you will basically be back down to your usual level of 75mg.
Are we giving enough clopidogrel and aspirin to prevent stent thrombosis? And as we know, there are different levels of IPAs (inhibition of platelet aggregation). that has been measured with patients who are taking clopidogrel, and..."
There are studies about aspirin resistance and plavix resistance and there are studies that say it's 20-40% of the population. Other studies, at least with aspirin, it's about less than 1% if you use the arachidonic acid based (testing).
If you’ve already had a heart attack or stroke or are resistant to the beneficial effects of aspirin, your doctor may suggest supplementary aspirin therapy with another clot-preventing drug, such as clopidogrel (Plavix). Clopidogrel may even be suggested as an alternative drug therapy, particularly if you’re allergic to aspirin or can’t tolerate its side effects."
Maybe someone will be able to add a thought or 2. Take care and keep us posted.
ve had arthralgia ,oseaophigitis,rashes and chest pain .
If you are referring to Plavix (clopidogrel) and Aspirin, I would take them for life. The general rule used to be aspirin for life, plavix for a year. However, more and more cases of forming clots in stents were appearing when plavix was stopped, so now the general trend is changing towards life.
The most widely studied and prescribed antiplatelet agent for the prevention of stroke and other serious vascular events among high vascular risk patients is aspirin. I take aspirin daily prior to CHF..
Plavix and aspirin for preventing stroke and other serious vascular events in high vascular risk patients. Up to one year after a stent implant, plavix and aspirin are the recommended protocol as statistics have shown a high risk for clot.
I was told there is no real evidence it reacts with clopidogrel (plavix) and if it does, the effect is tiny. My INR didn't change on this medication for 2 years. It would seem Aspirin is the culprit for causing my stomach issues, so I've been taken off aspirin and put back onto plavix for life.
Conclusions In this trial regarding CHARMISMA study, there was a suggestion of benefit with clopidogrel treatment in patients with symptomatic atherothrombosis and a suggestion of harm in patients with multiple risk factors. Overall, clopidogrel plus aspirin was not significantly more effective than aspirin alone in reducing the rate of myocardial infarction, stroke, or death from cardiovascular causes." (ClinicalTrials.
Hello; I have got one coronary DES stent implanted since two month ago ("Endeavor RESOLUTE RX"). I am on clopidogrel, aspirin, atorvastatin, carvedilol, enalapril and pantoprazol. Fearing about scars growing inside the stent's mesh, I have read that some people recommend vitamin E for cosmetic appearance of scars; well, my question is: Could vitamin E be of some help for preventing "in-stent restenosis"? Is it worth trying? Thanks!
ve already had a heart attack or stroke, or if you have been found by your doctor to be at high or moderate risk for heart attack or stroke, the benefits of taking aspirin can trump the risks. That’s because aspirin acts as an anti-inflammatory and an inhibitor of blood clotting. For those at risk, aspirin is one of the drugs in our arsenal (along with statins, ACE inhibitors, and beta blockers) that can help keep a coronary event from occurring in the first place or recurring.
Some of the alternatives include aspirin, Clopidogrel (Plavix), ticlodipine (Ticlid), dipyridamole (Persantine). Another alternative is Heparin injection. Different situations require different levels of anticoagulation. It is important to discuss the best treatment option with a physician.
However, the dose needs to be adjusted well. Also aspirin can be combined with Coumadin. Aspirin can be combined with clopidogrel also and reduces the risk of stroke. Please discuss these options with her treating doctor. The risks of giving these in dialysis and HIV will have to be seen in light of risks involved with strokes.
Take care!
To make this work as a routine he now has to continue with the blood thinner CLOPIDOGREL along with his usual Aspirin daily. Also a daily walking for one hour. I am so grateful to the Doctor who made it possible for my husband to get relief from his Angina. My question to the people who are on the same boat.....
Do you get an awful bruising easily? Some bruising is common I heard but my worries are regarding cerebral haemorrhage.
Based on the level of risk, most patients are either started on aspirin or Warfarin (Coumadin). Clopidogrel (Plavix) is an anti-platelet agent and acts via a different mechanism than coumadin does (coagulation pathway). Adding Clopidogrel to aspirin is a guideline that holds a Class 2b (see below) recommendation, and usually considered in those in which Warfarin is unsuitable due to patient preference or physician's assessment on a patient's ability to safely sustain anticoagulation.
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