While extending the duration of
clopidogrel use may decrease the
risk of very late stent thrombosis
events, this strategy may also result
in an increased risk for major bleeding complications and involves lifestyle modifications, such as deferral of surgical and dental procedures that may affect a patient's health and overall quality of life.
[Finally, it is known that stent thrombosis can occur in some individuals despite the continued use of dual antiplatelet therapy.