I do not often use benadryl in atopic cats, but I have had some success with chlorpheniramine 2-4mg/cat orally twice daily. In some cats, antihistamines
can cause sedation; rarely antihistamines
can cause paradoxical excitement, so discontinue them if side effects occur. Topical benadryl or hydrocortisone cream can also be tried on localized areas of skin inflammation, but since cats groom themselves, topical products may not be particularly helpful.