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At high concentrations in vitro, clopidogrel inhibits P450 (C). Accordingly, Plavix may interfere with the metabolism of phenytoin, tamoxifen, tolbutamide, warfarin, torsemide, fluvastatin, and many non-steroidal anti-inflammatory agents, but there are no data with which to predict the magnitude of these interactions. Caution should be used when any of these drugs is co administered with Plavix.
To date there have been no reports of an important interaction in humans between warfarin and clopidogrel. Nonetheless, because warfarin increases the risk of bleeding, blood tests to measure the degree to which the blood is anti-coagulated or thinned (prothrombin time; INR) may be ordered to assess the degree of blood-thinning when warfarin and clopidogrel are used together.
Enhanced hypoprothrombinemic response to warfarin has been reported in patients with acute alcohol intoxication and/or liver disease. The proposed mechanisms are inhibition of warfarin metabolism and decreased synthesis of clotting factors. Binge drinking may exacerbate liver impairment and its metabolic ability in patients with liver dysfunction. The risk of bleeding may be increased. Conversely, reductions in INR/PT have also been reported in chronic alcoholics with liver disease.
Unknown. Warfarin metabolism normally occurs through the cytochrome P450 (CYP450) isoenzyme system, with excretion occurring in the urine as inactive metabolites. It is postulated that large doses of acetaminophen may "exhaust" the capability of the CYP450 system to metabolize warfarin. Additionally, DARVOCET-N 100 TABLETS may reduce functional factor VII.
Management: Monitor coagulation status and adjust the dosage of COUMADIN 4MG TABLETS (BLUE) accordingly.
Given that yesterday he said to not take the warfarin he was changing me from the genertic warfarin and putting me on the brand name of the med coumadin. Said some folks do not tolerate warfarin well but do well on coumadin and i am to start the coumadin today. I would be lying if i didn't say i am a bit gunshy at this point. This med has made me absolutely miserable and today is my 43rd bday...
Binge drinking will increase your INR (ie effect of warfarin) and chronic drinking will decrease INR because your liver enzymes are chronically bumped which increases metabolism of warfarin (so your body eliminates it faster and get get less effect). Don't look a scape goat. You were put on a blood thinner to REDUCE your risk of a clot because YOU HAVE an INCREASED risk that outweighs the risk of being on a blood thinner.
Take ownership of your health and take care of yourself.
Does anyone know if having your Gallbladder removed slows down your metabolism? or does it speed it up? What have you experienced?
If you really want to kick-start your metabolism, you may also try dividing your meals up into smaller portions that you eat more often throughout the day. Every time you eat, it helps your metabolism rise, so as strange as it may sound, eating frequently can help you lose weight or maintain a healthy weight.
Take care!
DOES ANYONE KNOW IF WARFARIN CAN LOWER YOUR BLOOD COUNT AND AND ALSO LOWER CALCIUM AND VITAMIN D LEVELS?
ve tried to read as much as I can about warfarin along the way. I even went to a day-long CEU workshop for medical professionals on warfarin management and got the certificate. But I'm still not an expert. To my way of thinking, the experts are the hematologists, pharmacists, and other health professionals who manage large numbers of people's warfarin on a daily basis.
3 days later (boxing day) I was rushed to hospital with chest pains and diagnosed with self imposed pulmonary embolism. I was put on to Warfarin and monitored in hospital for 2 weeks.
t know how warfarin is affecting your life style. I have been on warfarin for years and had no concerns about running and bike riding, and using power wood working tools. All of these activities puts one at an increased risk of a cut and bleeding, but I simply take the risk. On the other hand, I don't sky dive, or pick fights ....
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