I have been on Coumadin for 18 years due to Lupus Anticoagulant (Antiphospholipid Syndrome) and several DVTs. In 2005 had MI with occlusion of the LAD artery and had drug stent inserted and I am still on plavix. My doc has debated when to take me off the Plavix safely....what are the recent studies about this dilemma? thanks so much!
To date there have been no reports of an important interaction in humans between warfarin and clopidogrel. Nonetheless, because warfarin increases the risk of bleeding, blood tests to measure the degree to which the blood is anti-coagulated or thinned (prothrombin time; INR) may be ordered to assess the degree of blood-thinning when warfarin and clopidogrel are used together.
During those times I had not yet been diagnosed and was able to go back to life like normal, however after the diagnosis and being on phenytoin and switching to oxcarbazepine i am feeling awful. Dizzy, nauseated, moody, extremely tired, severe headaches that come and go. All i get from my Neurologist is these are side effects that will eventually go away. Because i never know when these symptoms will come on too strong I have missed a lot of days at work during my probation period.
t know how warfarin is affecting your life style. I have been on warfarin for years and had no concerns about running and bike riding, and using power wood working tools. All of these activities puts one at an increased risk of a cut and bleeding, but I simply take the risk. On the other hand, I don't sky dive, or pick fights ....
This reaction is generally confined to the extremities but can affect the trunk and face and may be irreversible. Severe dermatologic reactions to phenytoin are infrequent. Some evidence, however, suggests that erythema multiforme is more likely in patients who undergo radiation therapy while receiving phenytoin.[22]
Lupus-like symptoms have been described for phenytoin. Whether phenytoin administration will exacerbate preexisting idiopathic systemic lupus erythematosus (SLE) is unclear.
ginger and glucosamine sulfate will affect coumadin (warfarin) I'm on warfarin and can't take ginger or glucosamine and a host of other supplements.
Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..."
It however says that initiation of Folic acid and phenytoin together is beneficial.
Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.
Seven months ago I had a pulmonary embolism and I am told this may have been the second one.I am taking 7 mg of warfarin a day and my INR is 2.5.I had a liver transplant 10 months ago,and was told my vascular system was not great.Given my overall situation I am concerned about heart attacks and strokes.Do you think I should be taking 75mg of aspirin a day as well as the warfarin?Thanks.
She has been on warfarin and monitors it regularly. She also has past history endometriosis and has always had heavy periods and problems with her periods. She also has uterine fibroids that have been giving her problems, even more so since the warfarin. Between the uterine fibroids and the warfarin, her menses are extremely heavy. She is on iron because she tends to be anemic around her period. Her periods are so heavy that she can go through 4-6 large pads an hour, sometimes more.
I believe it could be a FATAL mistake if you stopped taking the warfarin. Mechanical valves will clot without warfarin and this could cause a heart attack, stroke or heart failure and could cause you to have to have another open heart surgery. PLEASE ,PLEASE talk to your doctor about any changes in the warfarin.
A drastic change in diet can alter INR also, but in my own personal experience, it has usually been other meds that caused me to need to change my warfarin dosage and not my diet. An INR that is consistently out of range is dangerous. Don't worry about maintaining the same dose of warfarin. Worry about maintaining an INR that is consistently within range. Whatever dose of warfarin you have to take to stay in range is okay.
Sometimes aspirin is used in place of the Plavix, and the patient will be on aspirin and warfarin. That type of combo regimen is used when the doctor doesn't think that one drug alone is enough to do the job, and one drug obviously wasn't enough in your case. It seems that your Plavix and warfarin regimen is working, so I'll join you in giving thanks for that.
Moban® brand of molindone hydrochloride contains calcium ions which interfere with the absorption of phenytoin. Ingestion times of phenytoin and antacid preparations containing calcium should be staggered in patients with low serum phenytoin levels to prevent absorption problems”. Taken from http://www.rxlist.com/cgi/generic/phenyt_od.htm
Our population is divided into 4 type of metabolizers ranging from rapid to slow metabolizers depending upon the speed of elimination of drug from body.
Thank you for your question, you are relatively fine with Phenytoin and the seizure episodes in a form of lack of speech are the residue of a generalized type seizure. I don’t have a full description of your consciousness during the lack of speech episodes to decide whether this start is a partial epilepsy which can continue in a generalized or it is a generalized one from the first moment..
I was put on Warfarin immediately and have been on it ever since. Six weeks after starting the Warfarin, I had another TEE and the clots were 90% gone. They tried for seven and a half hours to do the ablation, but were not successful unfortunately. I will be on the Warfarin forever, but that is fine because you can’t eat leafy green veggies when you are on it and I despise green veggies so now I have the best excuse not to eat them.
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