I’ve gone through a few articles mentioning that diabetics with ED can use Generic Levitra (vardenafil). Is that true? If so, I’d like to know who has used Generic Levitra having ED and diabetes and is it safe.
Hi tmax.....You don't say how old she is, but more than likely, this is old age Arthritis as the weather becomes cooler.....Just the same for humans.....
Yes, a Vet visit is in order as they can prescribe the correct anti-inflammatories.....DO NOT to attempt to treat this w/OTC products......Ibuprofen is TOXIC to dogs & one dose of Aspirin can cause a Gastric bleed.....It is not worth the risk!
Prescribed meds. for Arthritis from your Vet will help her feel much better for many years..
The PDE5 inhibitors sildenafil, vardenafil and tadalafil are competitive and reversible inhibitors of cGMP hydrolysis by the catalytic side of PDE5.
Although rare, Viagra (sildenafil), Cialis (tadalafil) and Levitra (vardenafil) can cause muscle pain and unusual skin sensations or paresthesia. In clinical studies, Viagra caused muscle pain and paresthesia in less than 2% of patients. Patients who experience these side effects should stop taking the medication and consult their physician. These medications increase blood flow to the penis by inhibiting the enzyme phosphodiesterase type 5 (PDE5).
However, more variability was observed in some of the pharmacokinetic parameters for bupropion (AUC, Cmax, and Tmax) and its active metabolites (t½) in patients with mild to moderate hepatic cirrhosis.
The cheapest thing to try is generic glucosamine. It is a nutritional supplement that you can get at health food stores or even discount stores. I would get a name brand, because I got ripped off by buying one of the big box stores' house brand glucosamine one time, but you do not need to buy the most expensive brand. Sometimes it is sold in combination with chondroitin, but chondroitin makes my dogs itch.
As far as your erection problems and the penile length issues are concerned, you should start yourself on a 5 PDE (Phosphodiesterase type-5) inhibitor like sildenalfil or vardenafil under the care of urologist and see how you do. Once you have taken a trial of this drug, do get back to me and we can take it from there.
Hope that this information helps and hope that you will get better soon.
7 IU/mL (mean ± SD), with a median time of peak serum concentration (Tmax) of 16 hours. The serum elimination half-life (t1/2) was 69 ± 37 hours, and the
area under the serum concentration versus time curve (AUC) from zero to 96 hours was 294 ± 81 IU h/mL.
• Claiming that the time to peak plasma concentration (Tmax) of bupropion hydrochloride after ingesting Budeprion XL is identical to that in Wellbutrin XL, when studies have confirmed that the Tmax for Budeprion XL is less than one-half of that for Wellbutrin XL;
• Claiming that Budeprion XL did not carry with it a risk of dose dumping when taken with food, though reports have indicated that food may increase chance for toxicity;
• Claiming that human studies were done comparing Budeprion XL t
Effect of Food on Absorption of Ribavirin
Bioavailability of a single oral dose of Ribavirin was increased by coadministration with a high-fat meal. The absorption was slowed (Tmax was doubled) and the AUC0-192h and Cmax increased by 42% and 66%, respectively, when Ribavirin was taken with a high-fat meal compared with fasting conditions.
Good luck with treatment.
The absorption was slowed (Tmax was doubled) and the AUC0-192h and Cmax increased by 42% and 66%, respectively, when Ribavirin tablets were taken with a high-fat meal compared with fasting conditions [see Dosage and Administration (2.1) and Patient Counseling Information (17)].
http://www.drugs.com/pro/ribavirin.
Bioavailability of a single oral dose of Ribavirin was increased by coadministration with a high-fat meal. The absorption was slowed (Tmax was doubled) and the AUC0-192h and Cmax increased by 42% and 66%, respectively, when Ribavirin was taken with a high-fat meal compared with fasting conditions [see Dosage and Administration (2.1) and Patient Counseling Information (17)]."
"Ribavirin Dosage and Administration"
Ribavirin tablets should be taken with food.
The commonly prescribed drug by the doctors is sildenafil or Vardenafil (Levitra), which causes erections to be stronger and long lasting. However it may not be effective if you have uncontrolled diabetes, very low blood pressure (hypotension) or uncontrolled high blood pressure (hypertension), heart disease or heart failure, stroke or you are taking any nitrate drugs for angina, blood-thinning (anticoagulant) medications, antihypertensives or alpha blockers for enlarged prostate.
Bioavailability of a single oral dose of Ribavirin was increased by co-administration with a high-fat meal. The absorption was slowed (Tmax was doubled) and the AUC0-192h and Cmax increased by 42% and 66%, respectively, when Ribavirin tablets were taken with a high-fat meal compared with fasting conditions [see Dosage and Administration (2.1) and Patient Counseling Information (17)]."
Here is the link to this page:
http://www.drugs.com/pro/ribavirin.
The absorption was slowed (Tmax was doubled) and the AUC0-192h and Cmax increased by 42% and 66%, respectively, when Ribavirin tablets were taken with a high-fat meal compared with fasting conditions [see Dosage and Administration (2.1) and Patient Counseling Information (17)]."
I am not taking any chances. I need all the help I can get to get rid of this virus so I will eat another high fat meal at 6 pm.
medications such as phosphodiesterase type 5 inhibitors (such as sildenafil [Viagra], tadalafil [Cialis], vardenafil [Levitra]) or penile injections; surgery to correct blockages in the veins that drain the penis; or a penile implant.
Continue reading- https://24healthgoods.
(Costa Mesa, Calif)[19] showed minor effects on bioavailability, but a 33% increase in Tmax. A subsequent study by Schering-Plough Corporation (Kenilworth, NJ)[6] demonstrated more substantial increases in bioavailability: food increased the AUC and Cmax by 70% relative to the fasted population, and Tmax was more than doubled.
An initial study by ICN Pharmaceuticals, Inc. showed MINOR EFFECTS on bioavailability, but a 33% increase in Tmax (Time to Maximum Concentration)"
In other words, a high-fat breakfast (54 grams of fat) slowed the absorption of Ribavirin by 33%. It took 33% longer to reach the maximum concentration and had only a minor effect on bioavailability. So according to that study, eating a high fat meal had no benefit.
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