Intriguingly, treatment of DHBV congenitally infected ducks with the guanosine analog,
ganciclovir, efficiently reduced intrahepatic viral core DNA and reduced core antigen-positive hepatocytes. However, the treatment did not affect viral antigen expression in the bile duct epithelial cells, putative oval cells and DHBV-infected cells in extrahepatic sites such as the pancreas, kidney and spleen 67.