//www.medhelp.org/posts/Hepatitis-B/gilead-trl7-agonist-and-others-already-marketed/show/1685432#post_8125376
http://www.medhelp.org/posts/Hepatitis-B/gilead-trl7-agonist-and-others-already-marketed/show/1685432#post_8132560
http://www.medhelp.
For the first 39 months of use of entecavir/tenofovir there is not significant difference in HCC development for tenofovir vs entecavir for non-cirrhotic...as probably expected since pre-malignancy was probably already developed in those HCC cases. For Cirrhotic tenofovir maybe seems to be just slightly better option.
For non-cirrhotic usage of interferon in the past reduced chances of HCC by 29% in this study.
i am checking all pros and cons about entecavir/tenofovir combo vs entecavir mono for me and in general for all.
i am probably in cirrhosis or early cirrhosis and doctor put me in etecavir mono because of tenofovir kidney problems and possible discontinuation of tx but:
checking tenofovir trials on hbv only (no hiv coinfection) kidney problems are in less than 1% patients and i haven't found tx discontinuation because of kidney problems.
another important test is precore/bcp mutants test, adefovir, lamivudine and entecavir mutants test and genotype test
if you have no precore/bcp mutants your hbeag positive status will have 16% hbv clearance with the use of tenofovir plus entecavir, 24% tenofovir plus entecavir plus interferon.
Patients were treated with NAs therapy (lamivudine, adefovir, telbivudine, entecavir and tenofovir) for at least 2 years. qHBsAg was performed every 6 months.
Results
Our results showed a significantly greater qHBsAg decline after 2 years in patients treated with tenofovir (0.45 logIU/ml) than in patients treated with telbivudine (0.12 logIU/ml; P < 0.001).
Patients were treated with NAs therapy (lamivudine, adefovir, telbivudine, entecavir and tenofovir) for at least 2 years. qHBsAg was performed every 6 months.
Results
Our results showed a significantly greater qHBsAg decline after 2 years in patients treated with tenofovir (0.45 logIU/ml) than in patients treated with telbivudine (0.12 logIU/ml; P < 0.001).
Yes, I think they do have access to Entecavir.
Regarding to my LAM resistance, would Entecavir be easy to develop resistance as well? If yes, how effective is Tenofovir in that case?
Well you can try Tenofovir and see how you tolerate it. It supposed to be slightly better then Entecavir - meaning more potent. If you have issues with TDF (Viread) then stop and try Baraclude.
They are very comparable group of drugs. With Entecavir yes it is better to take it on an empty stomach.
What I do with Baraclude is I take it at night 4 -5 hours after a meal, and then I eat 8 hours after. I find it best to keep me functional.
p.s. you don't mention about your labs btw.
if you are hbeag positive tenofovir has 16% hbv clearance at 3 years while entecavir only 7%, hbvdna has no correlation with hbv clearance, only hbsag decrease has but if it is 89000iu/ml after 3 months you have no chances on entecavir to make it lower
the best treatment to clear hbv on hbeag positive now is tenofovir and then interferon add on, not entecavir
you can use tenofovir which is much much cheaper and more potent than baraclude
if you can order from india both etv and tdf generics are very cheap
tenofovir+entecavir if kidneys function is ok other wise entecavir only
hepatitistechnology can help regress cirrhosis faster and make liver function stable (google hepatitistechnologies)
please post all tests results so we can suggest what it is the best
it is also very very important to find a very expert liver specialist, not the one you have now
all these drugs must be started immediately, if too expensive there are generics:
tenofovir: tavin emcure or tenvir cipla
entecavir: ranbaxy
h
d never risk on etv, i actually don t want to risk on myself because resistance test detects only populations over 20% so i will combo
the bad side of combo etv+tnf or tenofovir mono vs etv mono is possible kidneys damage in less than 1% but making blood tests you can see before kidneys damage happens and change drug dose or drug while if resistance happens you cannot reverse it
tenofovir has 0% resistance so it cannot build any resistance while the opposite may happen with all the other antivirals
especially entecavir which makes many mutations for resistance....
sebvivo makes a mutant that makes lamivudine, entecavir useless, every doctor aware of hbv knows this
tenofovir is active on all mutants, and might be less potent only if q215s mutant from lamivudine is present or adefovir mutant is present so in your case it should work.
Recommended
