what do you think of telbivudine plus tenofovir pretreatment for 1-3 year and then peginterferon add on?i ve seen few immune studies on immunological effect of telbivudine and it worths pretreatment in combo tdf to prevent resistance.
i think it worths at least 12-24 weeks combo with peg with close monitoring for PN, but of course i understand no doctor likes to risk
some team in italy tried something similar but with very short time like 24weeks telbivudine mono and then peg intf add mono.
An extremely useful and clear research presentation that should clarify for many what to expect in terms of long term treatment in regard to surface antigen levels and amount of infected cells in the liver.
It also shows again the slight but noticeable advantage of starting treatment with a combo, that can later be followed by mono therapy.
Unfortunately the overall picture is not very encouraging in terms of loosing the infection.
Formed capsids are a prerequisit to begin the synthesis iof the DNA minus strand onthe inside of the still partially open capsids, later upon complete closure, the plus strand is synthesized by the same viral polymerase. At this stage the intracapsid supply of nucleotide presursors typically becomes too low to complete the plus strand, thus we have the famous gap in the plus strand of mature HBV virions.
That is actually not much better than tenofovir vs tenofovir disoproxil fumarate, the actual substance in Viread. It is 50 times more potent than tenofovir.
It is all this improper simplification of callling viread tenofovir.
Tenovovir, if it would be given orally, would have no effect on HBV.
TEnofovir if given intravenously or sc would still have almost no effect on HBV in the liver. the substance has a high negative charge and cannot easlily penetrate cell membranes.
During the illness, I took a course of antibiotics + antivirals - immunomodulators interferon synthesis inhibitors. These medicines affect the formation of antibodies or viral load or HIV seroconversion?
(20) The T69S insertion mutations, associated with resistance to multiple nucleoside analogues, are associated with resistance to tenofovir as well. Tenofovir resistance conferred by the T69S mutation or by multiple thymidine analogue resistance mutations appears to be multiplied if the M184V mutation is replaced by wild-type.(21) The K65R mutation, which may be selected by prior nucleoside analogue therapy, is associated with a modest decrease in sensitivity to tenofovir.
Association of Higher Plasma Vitamin D Binding Protein and Lower Free Calcitriol Levels with Tenofovir Disoproxil Fumarate Use and Plasma and Intracellular Tenofovir Pharmacokinetics: Cause of a Functional Vitamin D Deficiency?
"The finding of a 26% increase in vitamin D binding protein and a 42% decrease in free 1,25-OH(2)D between the lowest and highest quintiles of plasma tenofovir has not been previously reported.
The following is a paper from doctors in Francel. It said you can breastfeed whilst your are on Tenofovir because "Tenofovir is not absorbed in the breast milk". However, I have googled and cannot find any reference to this claim. All the best to you and your baby.
Clin Res Hepatol Gastroenterol.
2011 Jun 7. [Epub ahead of print]
Hepatitis B virus infection and pregnancy.
Pol S, Corouge M, Fontaine H.
Hi stef good day. U still there?? I have some question stef about taking tenofovir because i dont know what to do. Im start taking tenofovir september 2020 and i notice that february my urine have bubles until now my urine still foamy or bubles but in evening is normal.
Tenofovir can cause proteina stef??
tenofovir, no resistance
entecavir, 1,5% resistance but cannot be used on those using lamivudine because in this case resistance can go higher than 50%
interferon
if i had a doctor prescribing me such rubbish useless toxic.....i d destroy his life....
I am on tenofovir from March 2012 when i am pregnant at week 32. At that time i had hbs and hbe both positive.
e, other possible cause) which never grew and a huge attack in 2000 (brain MRI with lesions and history of Optic neuritis, 2 sets of SSEPs 4 years apart both abnormal and median abnormal above syrinx site which had shrunk and finally spinal tap which previously only showed elevated lymphs now had elevated Igg synthesis and index (apparently elevated 10X lab normal). Moved to new town and had myoclonus badly which bothered new neurologist but has been resolved.
Hi All,
Is there a way I can have a prescription from a doctor when buying tenofovir online? Here in the Philippines, the drug is not yet available and the doctors are not prescribing it since it is not available. I'm planning to take tenofovir but having trouble in getting prescription, so i cannot order online.
Please advise.
I took tenofovir from the 3rd trimester and my baby is fine till now but i stopped using it when she 2 months and start again 2 days ago since.
hbv has no symptoms, you may even be dying and feel nothing
tenofovir improves kideys function especially tenofovir+telbivudine in those with kidneys function.
http://pharmacychecker.com/Pricing.asp?DrugName=Tenofovir+Disoproxil+Fumarate&DrugId=59463&DrugStrengthId=105019
or
http://www.northdrugstore.com/buy-Viread.html
maybe this will help ... but have to check before because some fake drugs can be sell over the internet.
tenofovir is the oldest drug among hbv drug since we share the same drugs as hiv, it is the most potent and generics are on the market.
HBVDNA is not detectable, Fiboscan is normal. initially i went through PegIntreforen+ Tenofovir for 40 weeks in 2012 then i switch to only Tenofovir. Now it 3 yrs and 4 month on Tenofovir.
Last week my doctor told that you HbeAg should be non reactive after 2 yrs of Tenofovir but since it over 3 years so might be Tenofovir resistance So you need to change my medicine.
Please suggest me what i do.
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