TDF, tenofovir, and renal function: association with parathyroid hormone?The association of lower eGFR with TDF use (47–49) and higher plasma tenofovir concentrations (50) have been previously described. In this cross-sectional analysis, causality cannot be assessed; it may be that participants with the lowest pretreatment eGFR were the slowest to clear tenofovir.
It has been suggested that TDF-associated renal toxicity causes elevations in parathyroid hormone (17, 48).
if you have renal problems i would monitor and switch to entecavir if they get worse or stay out of range.there is many people here taking tenofovir for years, check what is their experience on this
talk with the doctor about switching to etv, did you have renal problems before starting tx?
Both etv and tdf have to be processed through renal tubes so both can impact kidneys but most people are ok. The Tenofovir TAF is supposed to be very good.
3. Entecavir in high doses in animal studies was causing cancer but no human cases reported yet.
4. Tenofovir has a stonger resistsnce profile for mutants.
There is two tenofovirs, TDF and TAF. TAF is the new one.
Tenofovir alafenamide (TAF), a new formulation that reaches higher levels in cells but allows for lower dosing, was as effective as the current tenofovir disoproxil fumarate (TDF) formulation but had less impact on markers of kidney function and bone turnover, researchers reported at the 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2013) this week in Denver.
Your only reasonable choice is tenofovir. Despite its chemical similarity, tenofovir is about 80 times less toxic to the kidneys than adefovir.
I remember a personal discussion about this with Gileads research director, Gibbs, at the time. He said "we had no idea, what a huge difference a single methyl group can make".
i was checking if there is anyway to prevent kidneys damage in cases like mine where kidenys cannot stand tenofovir, i don t have plans to add tenofovir for the moment but in any case i'd like to make sure i will be able to use it if ever needed.
this is what i have found,there are 3 antioxidants that help prevent kidneys damage:
co-q10, looks like the most potent since it has been used in patients with severe renal failure.Co Q10 for chronic renal failure
http://findarticles.
In addition, the study will evaluate the effect of sequential dosing with tenofovir for 12 weeks, following monotherapy SB 9200, for possible synergistic effects on the reduction of HBV DNA and HBsAg.”
This Phase 2a study has an adaptive trial design that will enroll 80 chronically-infected HBV patients between 18 and 70 years of age who will be assigned to one of four dosing cohorts, 25 mg, 50 mg, 100 mg or 200 mg of SB 9200, or placebo, once daily for 12 weeks.
http://seekingalpha.com/news/3170065-contravir-claims-cmx157-better-gileads-taf-hepatitis-b-shares-20-percent
Mar 29 2016, 13:02 ET | By: Douglas W. House, SA News Editor
Thinly traded nano cap ContraVir Pharmaceuticals (CTRV +20.
have read in many forums that lam is not the best, approached my doctor with this concern and she sugessted tenofovir. Should i start tenofovir immediately, how should i start. Should i just abruptly stop lam and move on to tenofovir, should i use both and gradually stop lam after a few day/weeks. No other options here. Nigeria (Africa), so i cannot combo with other drugs. NEED YOUR ADVICE HOUSE.
I am not aware that impaired renal function precludes treatment for HCV. I have read that kidney disease is a negative predictor of SVR but, so too are a lot of conditions yet people have overcome them. I have seen articles which discuss the plasma levels of ribavirin with renal impaired patients. The suggestion is that rather than weight base dose these patients the dose should be arrived at by considering GFR (glomerular filtration rate).
This is from Clinical Care Options @ http://tiny.
CMX157 decreased circulating levels of tenofovir, lowered systemic exposure and reduced the potential for renal and bone side effects."
Unfortunately, the reports by these financial advisors/reporters frequently lack the necessary precision. In this case the difference would be critical. I am not sure at this point what to trust, since in some presentations the company actually seemingly used simple Tenofovir, not TDF as a comparison drug.
There is a new version of Tenofovir in trials that is supposedly 200 times more potent than the TDF that is out now, boosting intracellular concentration, thus reducing any harmful renal effects:
http://www.chimerix.com/therapeutic-programs/category/cmx157/
https://docs.google.com/viewer?url=http%3A%2F%2Fwww.ihlpress.com%2Fpdf%2520files%2Fresistance08_presentations%2F06_Lanier_website.
It reactivated this year with a very high viral load of 170,000,000iu/ml. I started tenofovir last month and i was told it causes bone loss in long term use. Please how long would does start to cause the bone loss and how often do I have to check my bone density??
//www.medhelp.
By "AGE" I'm assuming you mean a persons age in years. I don't believe age has anything to do with Janumet's "effectiveness" but age has a larger role with renal function. To make it clear for other readers, Janumet is combination of two drugs; Sitagiptin and Metformin.
This a brief from the Merck web site - makers of Janumet - Section 8.5 - Geriatric Use JANUMET.
I also have kidney damage from a bout of high blood pressure 4 years ago, and I am a frequent kidney stone former, so I am being watched carefully by a nephrologist too. I have renal panels frequently too. I was wondering if any of this could increase my stone risk. I was reading about the cytomel and stones. The nephrologist wants me to remain on the synthroid and cytomel.
I think it depends on some individual factors, particularly renal clearance of the drug. I found this information in the drug reference:
According to the manufacturer's tests, the drug reaches maximum serum levels between 15 and 44 hours after subcutaneous injection of a single dose. The mean elimination half-life is 22 to 60 hours (mean = 40 hours). So, I would expect that after 7 days (4.2 half-lifes) that the concentration would be about 5.5% (0.5^4.2) of the maximum levels.
5 mg i want to switched her from entehep to tenofovir but i heard thai it has side effect on kidney and bone loss so how to overcome this situation.
in case of decline of gfr below 60 or 30, since renal failure is when gfr is below 15, tenofovir can be reduced to 150mg daily or 75mg daily and still fully active.at lower doses the drug still works even in case of lamR, i posted a study a couple of days ago on this who last 5 years without any tdf resistance, both doses are much more potent than adv
since only 1% needs to change dose due to low gfr below 30 it is better to keep full dose even if 150mg and 75mg work.
s novel, highly potent lipid conjugate of tenofovir for treating hepatitis B virus (HBV) infection. In order to facilitate enrollment, the study is being conducted by several leading academic medical centers in Thailand, a country in which the incidence of HBV is very high.
The Phase 1 portion of the study will enroll 50 healthy volunteers assigned to one of five sequential, ascending CMX157 dosing cohorts.
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