TDF, tenofovir, and renal function: association with parathyroid hormone?The association of lower eGFR with TDF use (47–49) and higher plasma tenofovir concentrations (50) have been previously described. In this cross-sectional analysis, causality cannot be assessed; it may be that participants with the lowest pretreatment eGFR were the slowest to clear tenofovir.
It has been suggested that TDF-associated renal toxicity causes elevations in parathyroid hormone (17, 48).
if you have renal problems i would monitor and switch to entecavir if they get worse or stay out of range.there is many people here taking tenofovir for years, check what is their experience on this
talk with the doctor about switching to etv, did you have renal problems before starting tx?
Both etv and tdf have to be processed through renal tubes so both can impact kidneys but most people are ok. The Tenofovir TAF is supposed to be very good.
3. Entecavir in high doses in animal studies was causing cancer but no human cases reported yet.
4. Tenofovir has a stonger resistsnce profile for mutants.
There is two tenofovirs, TDF and TAF. TAF is the new one.
Your only reasonable choice is tenofovir. Despite its chemical similarity, tenofovir is about 80 times less toxic to the kidneys than adefovir.
I remember a personal discussion about this with Gileads research director, Gibbs, at the time. He said "we had no idea, what a huge difference a single methyl group can make".
i was checking if there is anyway to prevent kidneys damage in cases like mine where kidenys cannot stand tenofovir, i don t have plans to add tenofovir for the moment but in any case i'd like to make sure i will be able to use it if ever needed.
this is what i have found,there are 3 antioxidants that help prevent kidneys damage:
co-q10, looks like the most potent since it has been used in patients with severe renal failure.Co Q10 for chronic renal failure
http://findarticles.
http://seekingalpha.com/news/3170065-contravir-claims-cmx157-better-gileads-taf-hepatitis-b-shares-20-percent
Mar 29 2016, 13:02 ET | By: Douglas W. House, SA News Editor
Thinly traded nano cap ContraVir Pharmaceuticals (CTRV +20.
have read in many forums that lam is not the best, approached my doctor with this concern and she sugessted tenofovir. Should i start tenofovir immediately, how should i start. Should i just abruptly stop lam and move on to tenofovir, should i use both and gradually stop lam after a few day/weeks. No other options here. Nigeria (Africa), so i cannot combo with other drugs. NEED YOUR ADVICE HOUSE.
CMX157 decreased circulating levels of tenofovir, lowered systemic exposure and reduced the potential for renal and bone side effects."
Unfortunately, the reports by these financial advisors/reporters frequently lack the necessary precision. In this case the difference would be critical. I am not sure at this point what to trust, since in some presentations the company actually seemingly used simple Tenofovir, not TDF as a comparison drug.
There is a new version of Tenofovir in trials that is supposedly 200 times more potent than the TDF that is out now, boosting intracellular concentration, thus reducing any harmful renal effects:
http://www.chimerix.com/therapeutic-programs/category/cmx157/
https://docs.google.com/viewer?url=http%3A%2F%2Fwww.ihlpress.com%2Fpdf%2520files%2Fresistance08_presentations%2F06_Lanier_website.
It reactivated this year with a very high viral load of 170,000,000iu/ml. I started tenofovir last month and i was told it causes bone loss in long term use. Please how long would does start to cause the bone loss and how often do I have to check my bone density??
5 mg i want to switched her from entehep to tenofovir but i heard thai it has side effect on kidney and bone loss so how to overcome this situation.
in case of decline of gfr below 60 or 30, since renal failure is when gfr is below 15, tenofovir can be reduced to 150mg daily or 75mg daily and still fully active.at lower doses the drug still works even in case of lamR, i posted a study a couple of days ago on this who last 5 years without any tdf resistance, both doses are much more potent than adv
since only 1% needs to change dose due to low gfr below 30 it is better to keep full dose even if 150mg and 75mg work.
browse all posts and you ll find all the answers, hbv is very very complicated even for most liver specialists and most are ignorant about it
the only cure is sequential treatment of tenofovir or entecavir for 5-10years and then peginterferon add on.hbsag quantity in iu/ml (abbott architect or elecsys roches) determines when to add and clearance of infection.
Since then, I have been taking Zeffix (Lamivudine). Recently my doctor decided to put me on Viread (Tenofovir) instead. As I have read, some people are experiencing bone density loss due to Tenofovir therapy. Is it advisable that I start taking supplements like calcium and vitamin D along with my therapy to prevent bone loss? Thank you.
So, recommendation from my local doctor and Stanford doctor is to start anti-virals with either entacavir or tenofovir. I had renal function checked (24 hour creatinine clearance) and it is normal. Sounds like tenofovir would be the preferred drug?
I am a little worried about starting treatment. I'm not a very high energy person, will it make me feel tired all the time? Also, how precisely does it need to be taken each day -- within a couple hours of the same time, or really exact?
at this point the best choice would be tenofovir which is much cheaper and much potent with no resistance detected until now, also nitazoxanide should work preventing resistance but i don t suggest that for this purpose since we only have in vitro studies and no in vivo trials about prevention of resistance
tenofovir has also a generic called tenvir (about 99usd), tenofovir is also sold at about 10usd or less per bottles in poor asian countries where the generic tenvir is taking all the market
has been reported to cause Fanconi syndrome, renal insufficiency as well as osteomalacia and decrease in bone density.
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