truvada is just tenofovir+ftc, it is sueless on hbv unless non response to tenofovir, which is extremely rare
it adds toxicity and higher price because truvada patent is not expiring in 2014, no difference on hbsag.
instead of truvada it is best only for those non responding to combo tenofovir+lamivudine.
No Detectable Resistance to Tenofovir Disoproxil Fumarate (TDF) Following up to 240 Weeks of Treatment in Patients with HBeAg+ and HBeAg- Chronic Hepatitis B Virus Infection
P. Marcellin1; E. Heathcote2; A. Corsa3; Y. Liu3; M. D. Miller3; K. M. Kitrinos3
1. Hopital Beaujon, University of Paris, Clichy, France.
2. Toronto General Hospital, Toronto, ON, Canada.
3. Gilead Sciences, Inc., Foster City, CA, United States.
also find amore expert doctor since you have had the worst managment of hbv possible making only damage
to have chances of eradicating hbv peginterferon+tenofovir+nitazoxanide (peg at least 2 years) would be the best choice in your case but peginterferon is expensive and can have sides
attention entecavir works only in naive patients and even in naive patients it has 1,2% resistance, truvada is tenofovir+ftc (ftc similar drug to lam) in combo to prevent resistance and of coruse it has zero resistance until now
entecavir is also less potent than tenofovir, tenofovir is the only drug with zero resistance until now, all other drugs have resistance mutations
entecavir mght be used in case of adefovir resistance or even better a combo of tenofovir and entecavir
the explanation of why tenofovir is so potent on hbv and makes no resistance was explained by the intracellular levels reached by this drug, it is so bad no study ever showed how all other nucs are extremely poor at this and when i found this comparison i was very very surprised
all ohter drugs are so weak as intracellular levels, just look at lam vs tdf.we dont have etv here but it is probably very poor too.
Ann8 just like with hepsera, if a primary resistance mutation to Tenofovir would occur, the simultaneous LAM will suppress the propagation of this mutated species, preventing it to get to higher numbers. This always is based of course on the assumption that no a priory LAM mutation is in existence. Thus now after many years it is now routinely recommended to start hepsera together with LAM.
if there is a way to predict development of mitochondrial myopathy or prevent it a combo of clevudine with another drug might be considered but at research level or monitoring very closely for sides
in vitro combo of clevudine and ftc made the strongest decline of ccdna, i guess truvada+clevudine might prevent resistance 100%, let's hope some researcher will check for this and make possible reduction or control of this very dangerous sides effect of mitochondrial myopathy (i think also te
there is also an old clinical report about this combo therapy, i dont know if you have seen it googleing around
another guy got hbv and hdv eradicated by 11months with the combo of interferon+truvada(tenofovir+FTC), he was hbeag pos and i dont remember if interferon was started first, anyway this combo lead to hbsag seroconversion very fast
other reports are from interferon+telbivudine with hbsag 1 log decrease by 24weeks only, the trial was stopped because of myophaty sides but telbivudine h
if you can stand interferon sides effects and cost
the good about inf is you can stop tx whenever you like and there is no resistance with this tx, good chance to get rid of the virus after 3-6years, the bad is you can have heavy sides (usually young people have few or no sides)
if you get hbvdna higher or alt/ast higher than 30ui/ml often i would start tenofovir (no resistance at 3 years and probably no resuistance at all on naive), the bad about antivirals is that you have to take them for l
tenvir is generic version of tenofovir
tenvir tm is generic version of tenofovir+emtricitabine (truvada) which even more potent than tenofovir alone
entecavir is less potent of both tdf or truvada, i am also on entecavir which is about 1000usd per month changing currency from euro, i have it free in my country but it is absurd to allow such costs for a stupid tablet
http://www.aids-drugs-online.com/productindex.
i really dont understand why use of truvada which is simply tenofovir plus ftc in one pill, tenofovir is the most potent drug against hbv replication and has no resistance so truvada has meaning as a business way to make money from patients with only side effects added to patients, truvada is more toxic on kidneys than tenofovir monotherapy
the only thing that may justify your doctor is the need to suppress hbv very fast in weeks instead of a couple of months but 151000iu/ml maybe suppressed in
the second component is unchanged, 200mg of emtricitabine, also called FTC, a fluor substituted form of Lamivudine, that provides protection from the development of mutants that will lower the responsiveness to tenofovir.
it's side effects are generally considered very mild, equivalent to lamivudine.
This is theoretically good news for hbv patients waiting eagerly for TAF to be available for HBV.
The problem is the high price: 1500$ for one month supply of 30 pills.
He was an ingenious organic chemist, developed first adefovir, then, together with de Clerq in Belgium Tenofovir a compound which has only one Methyl group additional attached to Adefovir, which was surprisingly reducing its toxicity by at least 50fold.
Due to the extremely low susceptibility to resistance and very low toxicity this drug became the cornerstone of antiviral treatment for HIV and HBV.
Baraclude/Viread/Sebivo, With FTC/L-FMAU soon) Downside: Potential damage
Issue 2: Drug Regime
Doctor recommends Baraclude or Viread. I would concur. Through both may be recommended based on high viral levels. Upside: Lower risk of resistance Downside: Lack of FDA trials on the Baraclude/Viread combination may mean unexpected interaction/side-effects.
Current Thought: Go Combo Baraclude/Viread when treatment is needed.
try nitazoxanide first and if you see no results add tenofovir (do not use the other tablet which is truvada it is tenofovir+ftc but you don t need it, it can have more sides than tenofovir alone and only if you have resistant mutants or tenofovir alone doesn t work can be used)
it makes sense to try ntz first or monitor for another 6-12 months because we have seen from a post there is a new formula for tenofovir with 4.
1) entecavir useless and much less potent than the other options below
2) lam+adv, much more potent than etv, no other resistance mutations development
3) tenofovir, best choice and if doesn t get hbvdna und tenofovir+ftc, no other resistance mutations development
since trial found that lam+adv is more potent than etv or adv monotherapy i think that it is better to keep etv+tnf
if you check in the community there is also a generic for etv made in india and i'd definitely choose tnf+etv+nt
what do you think of telbivudine plus tenofovir pretreatment for 1-3 year and then peginterferon add on?i ve seen few immune studies on immunological effect of telbivudine and it worths pretreatment in combo tdf to prevent resistance.
i think it worths at least 12-24 weeks combo with peg with close monitoring for PN, but of course i understand no doctor likes to risk
some team in italy tried something similar but with very short time like 24weeks telbivudine mono and then peg intf add mono.
Being a nervous mess since my possible exposure and feeling what I've read to be symptoms, I took the Home Access test at 7,11,14, and 19 weeks. These tests all came back negative. The consoleur and posting questions here, assured me that my tests were pretty much conclusive and my symptoms mean nothing. Anyways, I called the CDC to get some info on home access testing and they told me that the FTC has issued a warning about "home testing".
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