Tenofovir alafenamide (TAF), a new formulation that reaches higher levels in cells but allows for lower dosing, was as effective as the current tenofovir disoproxil fumarate (TDF) formulation but had less impact on markers of kidney function and bone turnover, researchers reported at the 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2013) this week in Denver.
In addition, the study will evaluate the effect of sequential dosing with tenofovir for 12 weeks, following monotherapy SB 9200, for possible synergistic effects on the reduction of HBV DNA and HBsAg.”
This Phase 2a study has an adaptive trial design that will enroll 80 chronically-infected HBV patients between 18 and 70 years of age who will be assigned to one of four dosing cohorts, 25 mg, 50 mg, 100 mg or 200 mg of SB 9200, or placebo, once daily for 12 weeks.
I am looking for articles that support TDF every other day or half dose. Can you provide links? As TDF was an HIV drug, they didn't really test dosing for HBV and just assumed same dose is fine. I believe that a lower dose may be just as effective, but I'd like to see if anyone has published on this.
//www.medhelp.
s novel, highly potent lipid conjugate of tenofovir for treating hepatitis B virus (HBV) infection. In order to facilitate enrollment, the study is being conducted by several leading academic medical centers in Thailand, a country in which the incidence of HBV is very high.
The Phase 1 portion of the study will enroll 50 healthy volunteers assigned to one of five sequential, ascending CMX157 dosing cohorts.
TAF contains less tenofovir than TDF, but it works smarter in the way that more of it gets absorbed in the liver, whereas only small portion of TDF gets absorbed in the liver.
1 tablet of TDF probably corresponds to the strength of 1 tablet of TAF (according to the strength/power of controling the virus), so if you cut it in half, you would be absorbing the half of the TAF/TDF dosage.
Whether that would be sufficient to control your virus, i have no idea.
Just tell me can Enteca match with BARACLUDE when comes to low dosing and precise dosing in conditions like CHB????No Gastro or Hepatologists should prefer the generics as the don't have any clinical trials...what they have only bioequivalance study and that a ******** study...if u want to debate just reply me buddy.
NCT02233075), patients with chronic HBV / HDV co-infection received once weekly dosing of 500mg REP 2139-Ca (calcium chelate complex) by 2h IV infusion for 15 weeks, followed by 15 weeks of combined therapy with 250mg REP 2139-Ca and 1 80ug Pegasys® and then 33 weeks with Pegasys® monotherapy.
That is actually not much better than tenofovir vs tenofovir disoproxil fumarate, the actual substance in Viread. It is 50 times more potent than tenofovir.
It is all this improper simplification of callling viread tenofovir.
Tenovovir, if it would be given orally, would have no effect on HBV.
TEnofovir if given intravenously or sc would still have almost no effect on HBV in the liver. the substance has a high negative charge and cannot easlily penetrate cell membranes.
Call your local pharmacist. We at MedHelp are not allowed to give out dosing instructions. Your pharmacist will be able to tell you exactly how to dose the medications. If your regular pharmacy is closed on Sunday, call any pharmacist availabe at your local grocery store or drug store such as Walgreens, CVS, or RiteAid.
(20) The T69S insertion mutations, associated with resistance to multiple nucleoside analogues, are associated with resistance to tenofovir as well. Tenofovir resistance conferred by the T69S mutation or by multiple thymidine analogue resistance mutations appears to be multiplied if the M184V mutation is replaced by wild-type.(21) The K65R mutation, which may be selected by prior nucleoside analogue therapy, is associated with a modest decrease in sensitivity to tenofovir.
Association of Higher Plasma Vitamin D Binding Protein and Lower Free Calcitriol Levels with Tenofovir Disoproxil Fumarate Use and Plasma and Intracellular Tenofovir Pharmacokinetics: Cause of a Functional Vitamin D Deficiency?
"The finding of a 26% increase in vitamin D binding protein and a 42% decrease in free 1,25-OH(2)D between the lowest and highest quintiles of plasma tenofovir has not been previously reported.
The following is a paper from doctors in Francel. It said you can breastfeed whilst your are on Tenofovir because "Tenofovir is not absorbed in the breast milk". However, I have googled and cannot find any reference to this claim. All the best to you and your baby.
Clin Res Hepatol Gastroenterol.
2011 Jun 7. [Epub ahead of print]
Hepatitis B virus infection and pregnancy.
Pol S, Corouge M, Fontaine H.
Hi stef good day. U still there?? I have some question stef about taking tenofovir because i dont know what to do. Im start taking tenofovir september 2020 and i notice that february my urine have bubles until now my urine still foamy or bubles but in evening is normal.
Tenofovir can cause proteina stef??
tenofovir, no resistance
entecavir, 1,5% resistance but cannot be used on those using lamivudine because in this case resistance can go higher than 50%
interferon
if i had a doctor prescribing me such rubbish useless toxic.....i d destroy his life....
I am on tenofovir from March 2012 when i am pregnant at week 32. At that time i had hbs and hbe both positive.
Hi All,
Is there a way I can have a prescription from a doctor when buying tenofovir online? Here in the Philippines, the drug is not yet available and the doctors are not prescribing it since it is not available. I'm planning to take tenofovir but having trouble in getting prescription, so i cannot order online.
Please advise.
I took tenofovir from the 3rd trimester and my baby is fine till now but i stopped using it when she 2 months and start again 2 days ago since.
hbv has no symptoms, you may even be dying and feel nothing
tenofovir improves kideys function especially tenofovir+telbivudine in those with kidneys function.
http://pharmacychecker.com/Pricing.asp?DrugName=Tenofovir+Disoproxil+Fumarate&DrugId=59463&DrugStrengthId=105019
or
http://www.northdrugstore.com/buy-Viread.html
maybe this will help ... but have to check before because some fake drugs can be sell over the internet.
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