Please, I am a 23 year old male from West Africa, I started taking tenofovir disoproxil fumarate for my chronic hepatitis b three months ago. But I read online that the drug causes bone demineralization, so I want to know if I have to take something else alongside the drug to avoid bone loss.
telbivudine plus tenofovir 12 months, discontinue telbivudine and add pegintf for another 12months
tenofovir protects from telbivudine resistance
telbivudine rescue immune system faster than other antivirals for pegintff add on
to cure hbv you need a researcher or very expert liver specialist, a simple liver specialist is not expert enough on these strategies
of all choices tenofovir must be present because it has the highest chance to clear hbv in your situation (no entecavir or other anti
Loss of bone mineral density (bone mass) has been documented in HIV-infected patients treated with tenofovir long-term. British researchers decided to monitor 122 tenofovir-treated hepatitis B patients to see if they also lost bone mass, and compare them to a control group of 48 untreated-patients.
Both the control group and treated patients were scanned by X-rays to measure bone mass.
1. A lot of people report kidney and bone issues with Tenofovir Disproxil Fumarate (TDF). Its supposed to be low but Ive seen a lot of members report it.
2. Both etv and tdf have to be processed through renal tubes so both can impact kidneys but most people are ok. The Tenofovir TAF is supposed to be very good.
3. Entecavir in high doses in animal studies was causing cancer but no human cases reported yet.
4. Tenofovir has a stonger resistsnce profile for mutants.
Has anyone on Tenofovir or Adefovir experienced bone loss especially in the jaw? My dentist said I have general bone loss of my jaw which is usually due to periodontitis, but my oral hygiene is great. I don't seem to have the classic signs of periodontitis. They are unsure why I have bone loss. I was wondering if it is related to these drugs. Seeking experiences from others on these drugs.
Members the first line oral anti viral for hepatitis b is tenofovir and according to doctor it is long life use. My question are 1) what is the efficacy and safety of tenofovir for says 10years or 15 years or 20years ? 2) what is the longest years of taking tenofovir that we have on record now?
The label on my bottle says to not take the tenofovir with ibuprofen. However, I previously asked my doctor if ibuprofen (among many other question I had) would be okay to take alongside it occasionally --- and he said it was no problem.
Hmmm. What to believe? The label or the doctor? o_O
Any personal experience with the interaction of these two medications?
I'm on Tenofovir for past 7 Years and My Serum creatinine is 1.1 mg/dL and eGFR is 86 % . Rest all the parameters like BUN,URIC acid are normal. LFT is normal and HBV PCR is undetected for past 7 years
Should I bother about the eGFR value ?
and found out she has hep B with high viral load. Doctor advised us to take Tenofovir to suppress the viral load at her FIRST trim but we are afraid might affect development of baby? and also i did some research, this pill usually was intro during the 3rd trim. Any feedback pls on our situation thanks!!
Tenofovir alafenamide (TAF), a new formulation that reaches higher levels in cells but allows for lower dosing, was as effective as the current tenofovir disoproxil fumarate (TDF) formulation but had less impact on markers of kidney function and bone turnover, researchers reported at the 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2013) this week in Denver.
CMX157 decreased circulating levels of tenofovir, lowered systemic exposure and reduced the potential for renal and bone side effects."
Unfortunately, the reports by these financial advisors/reporters frequently lack the necessary precision. In this case the difference would be critical. I am not sure at this point what to trust, since in some presentations the company actually seemingly used simple Tenofovir, not TDF as a comparison drug.
But as of the last few months Ive been experiencing what I think is Bone Thinning. My bones feel very weak and fragile as I continue to take viread. I cant workout anymore because its relatively hard. I was wondering what my options are in this situation?
tenofovir (viread) is much stronger than baraclude and has 0 resistance but have some mild sides in 1% cases of kidney toxicity and bone demineralization.seroconvertion on tenofovir is similar to interferon and in case of past use of lam with resistance or adefovir with no resistance is the best safe choice.
baraclude (entecavir) has 1.2% of resistance and on animal models causes cancer at doses 40 times higher than those in humans.
it has no sides, only less than 1% experience lowering of gfr so kidneys function must be controlled every month for the first 6 months of therapy to see if kidneys experience a decrease in gfr (creatinine is not good because you can have lower kidnys function and normal creatinine), other sides is loss of bone mineral density but if you have active hbv even liver damage leads to loss of bone mineral density and lower vitamin D
since this is only on less than 1% cases almost every drug can low
tenvir is generic version of tenofovir
tenvir tm is generic version of tenofovir+emtricitabine (truvada) which even more potent than tenofovir alone
entecavir is less potent of both tdf or truvada, i am also on entecavir which is about 1000usd per month changing currency from euro, i have it free in my country but it is absurd to allow such costs for a stupid tablet
http://www.aids-drugs-online.com/productindex.
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