I am a 25 year old female. I was diagnosed with a primary brain tumor in June 2008 and underwent surgery to remove it. It was the size of an apple and diagnosed a grade 2 tumor. It grew back in September 2008 and that's when i began rigorous radiation and oral chemotherapy (Temozolomide). My recent MRI has showed the regrowth of the tumor to be "gone." The plan is to take the Temozolomide for 2 years along with Accutane (which helps the oral chemotherapy work better).
ContraVir reports data shows CMX157 more potent against HBV than Gilead Viread
ContraVir Pharmaceuticals (CTRV) announced preliminary data dramatizing the unique properties of CMX157, the company's highly potent lipid prodrug of the successful antiviral drug tenofovir, or TFV. CMX157 was shown to be 60-fold more active than tenofovir against the hepatitis B virus, or HBV, based on in vitro studies.
Short Answer:
This depends on your metabolism, but in general it will stay in your system for 24-36 hours with a *low dose* (ie. no more than 30mg of codein). However with larger doses, it will be in your system for 48-72 hours depending on how high your dosage was.
Long Answer:
The half-life of codeine is 2.9 hours. This means that in 2.9 hours, only half the amount of codeine is remaining. In another 2.9 hours another half of that, and so on.
valtrex is an acyclovir prodrug. when you swallow it, during digestion the body turns it into acyclovir. because of this unique delivery method, you get more active acyclovir available in the body so you don't have to take it as often.
Even though valtrex is an acyclovir prodrug, some folks just do better on the acyclovir than they do the valtrex. My guess would be because you get less active acyclovir in your body with plain ole acyclovir than you do valtrex but we have no studies to back this assumption.
tenofovir disoproxil fumarate) is a prodrug of tenofovir. The 'disoproxil' is a side chain attached to the active component 'tenofovir'. Inside our body, this side chain gets cleaved off by an enzyme to release the active tenofovir. AGX-1009 has a different side chain attached to the active component 'tenofovir'. It may show higher potency and/or lower toxicity compared to Viread because of this different side chain (At least that's what Agenix is hoping for).
It is only more potent in the sense that as a prodrug of Tenofovir, just like the existing Viread(TDF), TAF converts to Tenofovir mainly in the liver cells, therefore has less side effects. But as Stef2011 stated, they reduced the dosage of TAF accordingly, so the same amount of Tenofovir is delivered to the liver cells as TDF. It would be really nice if they can do a proper dosage study of TAF/TDF specifically for HBV (and not use the same dosage for HIV/AIDS).
Valtrex is an acyclovir prodrug. Greatly simplified - you swallow valtrex and your body converts it into acyclovir inside the body. You get more active acyclovir available to kick a little herpes butt by doing it this way. That's why you take valtrex less often. We don't have studies to confirm that acyclovir reduces transmission the same amount as valtrex does but we assume it does.
http://racoon.com/herpes/v_a_compare.
we have over 20 years of info on taking daily suppressive therapy with acyclovir non-stop. valtrex is an acyclovir prodrug and we have no reason to think that it's any less safe. we have over 15 years of info on taking valtrex suppressively non-stop now too. there are no long term side effects. no reason to stop taking it unless you want to. why have more ob's than you have to is my motto plus if your partner is negative, it helps protect them too.
keep asking questions!
Last week I overdosed from taking approx. 4mls of GBL (a prodrug of GBH) and alcohol. Although I was deeply unconsious for several hours and had dangerously low heart rate and blood pressure. I spent the night in intensive care but was discharge the next morning. Since then I have made a full recovery, but have experienced heart pains and arrythmia at random moments. These usually last a few minutes and there is no disturbance in between these attacks.
Picking a well-tolerated opiate is usually a 'hit or miss' process. The differences in tolerability come from several factors. For example, for some opiates, the administered medication is a 'prodrug' that must be converted to the active drug by the liver; an example is the conversion of codeine to morphine, which is more efficient in some people than in others. There is also wide variation in the degree of nausea produced by different medications in different people.
I prescribe it almost exclusively now for my ADD patients, as it is very hard, if not impossible, to abuse-- it is a prodrug and requires activation, which takes time... so even if 'insufflated' there is no way for a teen to get a rush from the drug. It seems to hold its effects much longer than does provigil in my experience.
The grade 2 is your inflammation and activity of the virus itself. Fibrosis is scarring and it's reported in Stages. Cirrhosis is Stage 4 fibrosis. Your age and the fact that you are smoking anything can help the virus progress. As we age, the immune system is not as strong and people tend to progress more quickly. Smioking has also been shown to hurry the progression of the disease.
Valtrex is an acyclovir prodrug. Greatly simplified this means that you swallow valtrex and your body converts it into acyclovir. Because of this unique delivery system, you get more active acyclovir in the body to kick some herpes butt. Acyclovir works the same, you just have to take it 2x/day compared to once daily. I know with my insurance I pay under $20 for a 3 month supply which makes it WAY worth taking a pill 2x/day instead of once daily!
EDISON, N.J., Dec. 8, 2016 /PRNewswire/ -- ContraVir Pharmaceuticals, Inc. (CTRV), a biopharmaceutical company focused on the development and commercialization of targeted antiviral therapies, today provided new insights into the mechanism of action of its hepatitis B (HBV)-optimized cyclophilin inhibitor CRV431, showing that it effectively blocks a critical interaction between HBV X protein (HBx) and host cyclophilin A, with nanomolar potency.
], Stephan Menne
Abstract
SB 9200, an oral prodrug of the dinucleotide SB 9000, is being developed for the treatment of chronic hepatitis B virus (HBV) infection and represents a novel class of antivirals. SB 9200 is thought to activate the viral sensor proteins, retinoic acid-inducible gene 1 (RIG-I) and nucleotide-binding oligomerization domain-containing protein 2 (NOD2) resulting in interferon (IFN) mediated antiviral immune responses in virus-infected cells.
Sofosbuvir is an inhibitor of the HCV NS5B RNA-dependent RNA polymerase, which is required for viral replication. Sofosbuvir is a nucleotide prodrug that undergoes intracellular metabolism to form the pharmacologically active uridine analog triphosphate (GS-461203), which can be incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator.
We have info on over 25 years of acyclovir without any long term effects ( since valtrex is an acyclovir prodrug, same lack of issues but only 15 years of info on it which is still good ).
how often do you see your partner? if it's once a month or more, might as well just take suppressive therapy every single day.
When you take a 500mg valtrex tablet - you get about 55% of active acyclovir that actually survives the digestive process and is available to circulate thru your body and kick a little herpes butt when it finds it ( valtrex is an acyclovir prodrug which means you swallow valtrex but the body turns it into acyclovir ).
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