i wouldnt lower the tacrolimus dose further
The specialist reviewed all of the options with us - cyclosporine, pilocarpine or tacrolimus with sirolimus. She said that very rarely has she seen any dog respond to cyclosporine after not responding to tacrolimus. She also said that because our dog doesn't have a dry, goopy nose, that pilocarpine wouldn't be a first choice. She recommended a mix of tacrolimus with sirolimus. She said sirolimus is new. I have not been able to find anything about this drug on the internet.
His cretanine is almost 1.4 or around. My question is that should he continue his TACROLIMUS tablets or should switch to some other tablets which are safe for kidneys?
Secondly , in my sorrounding there is an opinion that lowering the TACROLIMUS dose also let the liver enzymes to increase? Do you favour such opinions as my father has lowered his tacrolimus dose to keep his kidneys safe?
Sir ,will wait for your kind reply.
Thanks.
s hard to perform my job or other daily tasks when my eyelids are so inflamed. I guess steroids are the only option until they develop something better. Is Tacrolimus a promising nonsteroidal option?
The treatments of this condition are application of topical corticosteroids (betamethasone, clobatesol, flucinolone) which will reduce the inflammatory process. Topical immunomodulators like pimecrolimus and tacrolimus can be used in severe conditions.
I hope it helps. It is very difficult to precisely confirm a diagnosis without examination and investigations and the answer is based on the medical information provided. For exact diagnosis, you are requested to consult your doctor.
Hormonal contraceptives such as the pill and the patch may increase the blood level of tacrolimus. Tacrolimus may also reduce the effectiveness of these hormonal contraceptives. For this reason women who could get pregnant should ideally use a non-hormonal method of contraception, eg condoms, to prevent pregnancy while taking this medicine. Seek advice from your doctor or pharmacist.
there are prograf assistance programs that the company offers. If this is not feasible than using other cheaper medications such as verapamil for example for HTN for example will alllow much lower doses of prograf to be used (it delays metabolism of the medication) and thus it comes out cheaper.
Please get a complete hormone panel ESH, LH, estrogen, progesterone and see if there is an imbalance. Hormone replacement therapy will help. With metal toxicity, certain chelating agents are given which bind with the metal and remove them from the body. Normal detox diet will not take care of that. It basically increases the antioxidants in the body.
Hope this helps. Take care!
AS I HAVE SUFFERED BREATHLESSNESS AND WALKING PROBLEMS,I HAVE BEEN TAKEN OFF TACROLIMUS AND PUT ON NEORAL-YET THERE IS NO IMPROVEMENT IN MY CONDITION.IS THERE ANY OTHER ANTI REJECTION DRUG THAT YOU WOULD RECOMMEND (I HAVE HAD A LIVER TRANSPLANT RECENTLY)? IN YOUR EXPERIENCE,CAN MY SITUATION BE IMPROVED?THANKS.
i would be extremely cautious about using it until more data is available especially since its purported effects on tacrolimus and cyclosporine metabolism are extreme. i am quite confident that there will be clinical trials coming down the road extremely soon.
My tacrolimus level is 4.2 after 4 months of liver transplant, Is it dangerous? what should i do?
Treatment is by topical steroids or oral therapy of corticosteroids in severe cases. Topical creams like tacrolimus ointment (Protopic) and pimecrolimus cream (Elidel) are also useful.
If still the symptoms do not improve then please get a clinical examination done by a dermatologist.
I hope it helps. Take care and please do keep me posted in case you have any additional doubts. Kind regards.
I have had really bad issues with walking, now requiring a can, for about a year. Diagnosed with Spinal Stenosis. It's gotten so bad that I started doing research. I have been doing 5-day energy shots daily for 6 months now - about 40mg of B6 per day (was doing emergen-c's before that). I'm thinking my walking, tingling may indeed be B6 toxicity and am going for a blood test this afternoon. I've gotten a lot of good information from this group - thank you.
I am having all of the symptoms related to B6 toxicity. I do not take vitamin supplements and have a healthy diet. What can cause me to have such a high b6 level if I am not taking supplements? My doctor asked me to give him a month to figure it out but I am in pain and want some answers.
I have been diagnosed with B6 toxicity. My doctor said that exercise would be good because it would speed metabolism. However, I'm concerned about doing what is best to heal my nerves. Since walking makes my feel hurt, throb, and twitch, I'm guessing that walking would actually hurt the healing process, not help. What has everyone else's experience been with healing from B6 toxicity and exercise? Do you think exercise helps or hinders the healing process?
Is it possible that my antimony level, more that twice and a half the normal range, could be causing me toxicity symptoms?
I RECENTLY STOPPED TAKING 400 MG OF PLAQUENIL DUE TO RETINAL TOXICITY. I TOOK THIS MED. FOR 20 PLUS YEARS. NOW MY VISION IS BLURRY LIKE LOOKING THROUGH A FOG HOWEVER I CAN READ THE EYE CHART AT 20/25. MY EYES ARE ALSO SENSITIVE TO THE SUN. MY QUESTION IS WHAT ARE MY CHANCES OF MY VISION RETURNING TO NORMAL.
PS I ALSO TAKE OTHER ANTI INFLAMMATORY DRUGS FOR RA.
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