Transplantation was done in Egypt 25-5-2008, I did very well for 2 months and then ler enzyme start to rise , liver biobsy revealed mild rejection, adjustment of tacrolimus was done.but liver enzymes cntinue to rise.MRCP was done and reveaed mid dilatation of hepatic ductes and ERCP and stenting was done 1.5 month ago.
Although bilirubin both direct and total, albumin, prothrombin, C.B.
i wouldnt lower the tacrolimus dose further
The specialist reviewed all of the options with us - cyclosporine, pilocarpine or tacrolimus with sirolimus. She said that very rarely has she seen any dog respond to cyclosporine after not responding to tacrolimus. She also said that because our dog doesn't have a dry, goopy nose, that pilocarpine wouldn't be a first choice. She recommended a mix of tacrolimus with sirolimus. She said sirolimus is new. I have not been able to find anything about this drug on the internet.
His cretanine is almost 1.4 or around. My question is that should he continue his TACROLIMUS tablets or should switch to some other tablets which are safe for kidneys?
Secondly , in my sorrounding there is an opinion that lowering the TACROLIMUS dose also let the liver enzymes to increase? Do you favour such opinions as my father has lowered his tacrolimus dose to keep his kidneys safe?
Sir ,will wait for your kind reply.
Thanks.
s hard to perform my job or other daily tasks when my eyelids are so inflamed. I guess steroids are the only option until they develop something better. Is Tacrolimus a promising nonsteroidal option?
The treatments of this condition are application of topical corticosteroids (betamethasone, clobatesol, flucinolone) which will reduce the inflammatory process. Topical immunomodulators like pimecrolimus and tacrolimus can be used in severe conditions.
I hope it helps. It is very difficult to precisely confirm a diagnosis without examination and investigations and the answer is based on the medical information provided. For exact diagnosis, you are requested to consult your doctor.
Hormonal contraceptives such as the pill and the patch may increase the blood level of tacrolimus. Tacrolimus may also reduce the effectiveness of these hormonal contraceptives. For this reason women who could get pregnant should ideally use a non-hormonal method of contraception, eg condoms, to prevent pregnancy while taking this medicine. Seek advice from your doctor or pharmacist.
there are prograf assistance programs that the company offers. If this is not feasible than using other cheaper medications such as verapamil for example for HTN for example will alllow much lower doses of prograf to be used (it delays metabolism of the medication) and thus it comes out cheaper.
AS I HAVE SUFFERED BREATHLESSNESS AND WALKING PROBLEMS,I HAVE BEEN TAKEN OFF TACROLIMUS AND PUT ON NEORAL-YET THERE IS NO IMPROVEMENT IN MY CONDITION.IS THERE ANY OTHER ANTI REJECTION DRUG THAT YOU WOULD RECOMMEND (I HAVE HAD A LIVER TRANSPLANT RECENTLY)? IN YOUR EXPERIENCE,CAN MY SITUATION BE IMPROVED?THANKS.
i would be extremely cautious about using it until more data is available especially since its purported effects on tacrolimus and cyclosporine metabolism are extreme. i am quite confident that there will be clinical trials coming down the road extremely soon.
My tacrolimus level is 4.2 after 4 months of liver transplant, Is it dangerous? what should i do?
Treatment is by topical steroids or oral therapy of corticosteroids in severe cases. Topical creams like tacrolimus ointment (Protopic) and pimecrolimus cream (Elidel) are also useful.
If still the symptoms do not improve then please get a clinical examination done by a dermatologist.
I hope it helps. Take care and please do keep me posted in case you have any additional doubts. Kind regards.
The 3-year patency rates after stent implantation ranged from 63% to 66%, regardless of the clinical indication or lesion type. The end point was the in-stent percentage of mean diameter stenosis within 6 months. The coated-stent arm demonstrated a greater in-stent mean diameter, with a 0% restenosis rate, as compared with the bare-stent arm, which had a 23.5% restenosis rate. Stress fractures within the stent struts occurred in several cases in the coated-stent arm.
One year later the stent had to be cleaned out. In 2008, another stent was placed inside that stent. In 2009 another stent was placed inside that stent. In 2010 that had to be re-expanded. OK, these are all drug eluding stents and two different drugs. My cardiologist seems to have no ideas on how to proceed on this for any better fix and he fully expects this to continue to give problems.
4 weeks ago in the emerjency room the doctor put me urinary stent becouse of infection and stones in my uretra. Now I finished takink medication they recomended me. Ther is no more infection in my urine. I vant to remove the stent and the stones, becouse it hurts me too much, and I cant take animore. But the doctor said thad I need 2 more monts the stent to be inside me. Why? I cant wait, I have too much pain. Do I have right to request removal of the stent?
Usually if it does not happen in the first year after the intervention it will not happen thereafter. The stent will then last forever. If it does occur, the stent can be reopened with a second intervention and another stent (usually drug eluting) can be placed within that stent. Make sure that you cholesterol is optimally controlled, LDL close to 70, HDL as high as possible (at least greater than 45, optimally close to 60).
I just had a stent procedure on Friday Februay 8th 2008 in my rca and had one in my circumflex in June of 2007. Before the Feb stent I was having shortness of breath, dizzyness and lightheadedness and was on Imdur. Now it has been 2 days and the dizzyness and lightheadedness is gone, however the shortness of breath is still going on even when I am just sitting? My cardiologists took me off of the Imdur.
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