Ive been diagnosed for membranous nehropathy from past 1 and a half years now with wyslone initially 50mg everyday and now 5 mg on alternate days, along with the immunosuppresent Tacrolimus 10 mg per dayto 6mg perday now. Still my protein outflow has not reuced completely ...Can you advise?
Hormonal contraceptives such as the pill and the patch may increase the blood level of tacrolimus. Tacrolimus may also reduce the effectiveness of these hormonal contraceptives. For this reason women who could get pregnant should ideally use a non-hormonal method of contraception, eg condoms, to prevent pregnancy while taking this medicine. Seek advice from your doctor or pharmacist.
i wouldnt lower the tacrolimus dose further
I was initially taking Tacrolimus and then I was switched to Sirolimus. I cannot remember why my immunosuppressive was changed but Sirolimus was pretty new then and maybe my surgeon wanted to try it and see how I did. I wasn't very fond of it as I recall. It came in small packets and was an oily solution. It's been a while but I do remember that. I probably mentioned this to my surgeon and that could be the reason that he switched me back.
and the Creatinine level at that was 1.5 - 1.6. The doctor reduced the tacrolimus dose to .5 mg morning and evening and since then the Creatinine level is slowly increasing. It is now between varying between 2.1 and 2.4. The TAC level is also low and reduced from 4.5 to 3.4 to 2.4 when last checked 2 months ago. Had a biopsy 2 months back and the report was OK.
Pl suggest.
The specialist reviewed all of the options with us - cyclosporine, pilocarpine or tacrolimus with sirolimus. She said that very rarely has she seen any dog respond to cyclosporine after not responding to tacrolimus. She also said that because our dog doesn't have a dry, goopy nose, that pilocarpine wouldn't be a first choice. She recommended a mix of tacrolimus with sirolimus. She said sirolimus is new. I have not been able to find anything about this drug on the internet.
He was tested positive for ebv but afetr reduced tacrolimus dose by1 mg per day his ebv is negative. Also his biopsy reports does not indicated auto Immune hepatitis.Please let me know what is the right mathod or treatment to get his IgG and protien level normal.
Thank you for your previous respose.
my daughter aged 13 years have only one white patch on knee she is prescribed melgain lotion tacrolimus ointment 1%, dicaris tablet50 mg(levamisol 50 mg) melanocyl tablets (methoxasalen) o.d I am confused about two different dermatologists prescriptions one has advised melgain in night other has in day followed by sun exposure. one has written melanocyl tab once a day other has not written this tab.
His cretanine is almost 1.4 or around. My question is that should he continue his TACROLIMUS tablets or should switch to some other tablets which are safe for kidneys?
Secondly , in my sorrounding there is an opinion that lowering the TACROLIMUS dose also let the liver enzymes to increase? Do you favour such opinions as my father has lowered his tacrolimus dose to keep his kidneys safe?
Sir ,will wait for your kind reply.
Thanks.
However my extremely flaky/seemingly dry lips remain. Am I right in thinking that the lips are caused by having taken 40 mg a day of accutane for 5 mths up until April of 09, or could they be a result of my seborrheic dermatitis? I had the flaking on the lips before accutane but i was also using 400 mg a day of doxycycline for 4 yrs. prior to accutane so that could have been causing the dryness?
s hard to perform my job or other daily tasks when my eyelids are so inflamed. I guess steroids are the only option until they develop something better. Is Tacrolimus a promising nonsteroidal option?
The treatments of this condition are application of topical corticosteroids (betamethasone, clobatesol, flucinolone) which will reduce the inflammatory process. Topical immunomodulators like pimecrolimus and tacrolimus can be used in severe conditions.
I hope it helps. It is very difficult to precisely confirm a diagnosis without examination and investigations and the answer is based on the medical information provided. For exact diagnosis, you are requested to consult your doctor.
there are prograf assistance programs that the company offers. If this is not feasible than using other cheaper medications such as verapamil for example for HTN for example will alllow much lower doses of prograf to be used (it delays metabolism of the medication) and thus it comes out cheaper.
AS I HAVE SUFFERED BREATHLESSNESS AND WALKING PROBLEMS,I HAVE BEEN TAKEN OFF TACROLIMUS AND PUT ON NEORAL-YET THERE IS NO IMPROVEMENT IN MY CONDITION.IS THERE ANY OTHER ANTI REJECTION DRUG THAT YOU WOULD RECOMMEND (I HAVE HAD A LIVER TRANSPLANT RECENTLY)? IN YOUR EXPERIENCE,CAN MY SITUATION BE IMPROVED?THANKS.
Oral antifungal drugs and immunomodulators such as tacrolimus and pimecrolimus are used in very severe cases. You can consult your dermatologist and discuss the treatment options of oral antifungals. Hope it helps. Take care and please do keep me posted if you have any additional queries. Warm regards.
i would be extremely cautious about using it until more data is available especially since its purported effects on tacrolimus and cyclosporine metabolism are extreme. i am quite confident that there will be clinical trials coming down the road extremely soon.
My tacrolimus level is 4.2 after 4 months of liver transplant, Is it dangerous? what should i do?
Treatment is by topical steroids or oral therapy of corticosteroids in severe cases. Topical creams like tacrolimus ointment (Protopic) and pimecrolimus cream (Elidel) are also useful.
If still the symptoms do not improve then please get a clinical examination done by a dermatologist.
I hope it helps. Take care and please do keep me posted in case you have any additional doubts. Kind regards.
Not the right place for this question. Sorry.
I am taking Tacrolimus 3mg, Myfortic 360mg, twice a day. My Creatine is 1.25 and BUN is 29. I am also interested in your opinion.
Meds - prednisone 5 mg qd for arthritis, Atopica 50 mg qod (off label use for arthritis; he had been on pred 10-15 mg qd, and decreasing it would make his s/s worse, so vet added Atopica - this was an informed decision), diazepam 2.5 mg bid for bladder, and famotidine (1/2 OTC tablet bid). He has had frequent bouts of diarrhea - used to happen every two weeks (from the time of his disc rupturing) and now occur about every 6-8 months.
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