i wouldnt lower the tacrolimus dose further
The latest FDA warning for PPI's (nexium is a PPI) is hypomagnesemia - magnesium deficiency.
"FDA notified healthcare professionals and the public that prescription proton pump inhibitor (PPI) drugs may cause low serum magnesium levels (hypomagnesemia) if taken for prolonged periods of time (in most cases, longer than one year).
The specialist reviewed all of the options with us - cyclosporine, pilocarpine or tacrolimus with sirolimus. She said that very rarely has she seen any dog respond to cyclosporine after not responding to tacrolimus. She also said that because our dog doesn't have a dry, goopy nose, that pilocarpine wouldn't be a first choice. She recommended a mix of tacrolimus with sirolimus. She said sirolimus is new. I have not been able to find anything about this drug on the internet.
His cretanine is almost 1.4 or around. My question is that should he continue his TACROLIMUS tablets or should switch to some other tablets which are safe for kidneys?
Secondly , in my sorrounding there is an opinion that lowering the TACROLIMUS dose also let the liver enzymes to increase? Do you favour such opinions as my father has lowered his tacrolimus dose to keep his kidneys safe?
Sir ,will wait for your kind reply.
Thanks.
s hard to perform my job or other daily tasks when my eyelids are so inflamed. I guess steroids are the only option until they develop something better. Is Tacrolimus a promising nonsteroidal option?
The treatments of this condition are application of topical corticosteroids (betamethasone, clobatesol, flucinolone) which will reduce the inflammatory process. Topical immunomodulators like pimecrolimus and tacrolimus can be used in severe conditions.
I hope it helps. It is very difficult to precisely confirm a diagnosis without examination and investigations and the answer is based on the medical information provided. For exact diagnosis, you are requested to consult your doctor.
Hormonal contraceptives such as the pill and the patch may increase the blood level of tacrolimus. Tacrolimus may also reduce the effectiveness of these hormonal contraceptives. For this reason women who could get pregnant should ideally use a non-hormonal method of contraception, eg condoms, to prevent pregnancy while taking this medicine. Seek advice from your doctor or pharmacist.
there are prograf assistance programs that the company offers. If this is not feasible than using other cheaper medications such as verapamil for example for HTN for example will alllow much lower doses of prograf to be used (it delays metabolism of the medication) and thus it comes out cheaper.
AS I HAVE SUFFERED BREATHLESSNESS AND WALKING PROBLEMS,I HAVE BEEN TAKEN OFF TACROLIMUS AND PUT ON NEORAL-YET THERE IS NO IMPROVEMENT IN MY CONDITION.IS THERE ANY OTHER ANTI REJECTION DRUG THAT YOU WOULD RECOMMEND (I HAVE HAD A LIVER TRANSPLANT RECENTLY)? IN YOUR EXPERIENCE,CAN MY SITUATION BE IMPROVED?THANKS.
i would be extremely cautious about using it until more data is available especially since its purported effects on tacrolimus and cyclosporine metabolism are extreme. i am quite confident that there will be clinical trials coming down the road extremely soon.
My tacrolimus level is 4.2 after 4 months of liver transplant, Is it dangerous? what should i do?
Muscle cramps can be very disturbing and can occur in many situations, like rest or nocturnal cramps, fatigue cramps, hyponatremia, hypocalcemia or tetany, hypomagnesemia, hypokalemia, contractures. Also inherited in MacArdle’s disease, protective reflex from injury, hypokalemia. Certain issues have been ruled out, get a fresh investigation done for the others. Considering her age group, muscular dystrophies also need contemplation. pseudo tumor cerebri is not associated with muscle cramps.
You need to rule out electrolyte disturbances like hypocalcemia, hyponatremia, hypo and hyper kalemia, hypomagnesemia and hypoglycemia. metabolic conditions like hypothyroidism, hyperthyroidism related myopathy, drugs like salbutamol, alcohol consumption, amyotrophic lateral sclerosis, parenteral nutrition, hyperventilation etc.
Treatment is by topical steroids or oral therapy of corticosteroids in severe cases. Topical creams like tacrolimus ointment (Protopic) and pimecrolimus cream (Elidel) are also useful.
If still the symptoms do not improve then please get a clinical examination done by a dermatologist.
I hope it helps. Take care and please do keep me posted in case you have any additional doubts. Kind regards.
So far all tests, echo, chest xray, bloodwork is coming back normal. I have been researching and my symptoms seem to match with hypomagnesemia. My magnesium was 0.89 and my doctor said this is perfectly normal. Well, if the normal range is from 1.5 then wouldn't this be low? Can anyone clarify this for me?
Muscle cramps can be due to simple causes like muscle fatigue, heavy exercise, dehydration, hypothyroidism, hypomagnesemia and hypocalcemia, side effectsof drugs like diuretics, caffeine. muscle cramps are cause by more serious neurological causes like motor neuron disease, muscle diseases, denerevation usually accompanied by weakness and atrophy of the affected muscle group etc. You need to see a neurologist to examine you in detail and check these symptoms. Hope this helps, take care.
Has possible hyperaldosteronism been tested? Have you hypomagnesemia? Do you use liqorice or diuretics? Your renal arteries may have become narrowed due to the ureter reimplantation. Was it done near the kidneys or near the bladder?
Not the right place for this question. Sorry.
I am taking Tacrolimus 3mg, Myfortic 360mg, twice a day. My Creatine is 1.25 and BUN is 29. I am also interested in your opinion.
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