It appears all beta blockers can cause hyperkalemia (higher than normal potassium level). Hyperkalemia secondary to beta-adrenergic receptor blockade can occur in 1% to 5% of patients and is more likely to occur in non-cardio-selective beta-blockers versus cardio-selective beta-blockers. Underlying cause can be excessive potassium intake, disturbed cellular uptake of potassium, or impaired renal excretion of potassium.
High potassium in your blood (Hyperkalemia) if it's not because of your kidneys function, is associated with some medical conditions eg Lupus, Diabetes, Addison disease, hormonal disorders etc but if there isn't a medical condition causation, it can also be caused by diet and medications....
"Medications that have been linked to hyperkalemia include:
-Antibiotics, including penicillin G and trimethoprim.
You are correct ACE inhibitors may cause hyperkalemia (high level of potassium). It seems potassium is normally excreted by the kidneys, so disorders that decrease the function of the kidneys can result in hyperkalemia. The kidneys normally remove excess potassium from the body. Therefore, most cases of hyperkalemia are caused by disorders that reduce the kidneys' ability to excrete potassium.
Sorry you wife took a turn for the worse and had to be admitted.
Here is a link to some information on high potassium in the blood (hyperkalemia).
http://www.webmd.com/a-to-z-guides/hyperkalemia-causes-symptoms-treatments
Quote:
"If you have hyperkalemia, you have too much potassium in your blood. The body needs a delicate balance of potassium to help the heart and other muscles work properly.
i wouldnt lower the tacrolimus dose further
The specialist reviewed all of the options with us - cyclosporine, pilocarpine or tacrolimus with sirolimus. She said that very rarely has she seen any dog respond to cyclosporine after not responding to tacrolimus. She also said that because our dog doesn't have a dry, goopy nose, that pilocarpine wouldn't be a first choice. She recommended a mix of tacrolimus with sirolimus. She said sirolimus is new. I have not been able to find anything about this drug on the internet.
Except for hyperkalemia, T wave abnormality alone is not diagnostic of any particular condition. There is no connection to MS. Additionally a "T" wave abnormality requires supporting evidence with other tests and relevant signs and symptoms. You shouldn't be too concerned about a EKG test as it is often false positive...it is only a tool for further dx.
Hope this helps, and if you have any further questions you are welcome to respond. take care.
His cretanine is almost 1.4 or around. My question is that should he continue his TACROLIMUS tablets or should switch to some other tablets which are safe for kidneys?
Secondly , in my sorrounding there is an opinion that lowering the TACROLIMUS dose also let the liver enzymes to increase? Do you favour such opinions as my father has lowered his tacrolimus dose to keep his kidneys safe?
Sir ,will wait for your kind reply.
Thanks.
s hard to perform my job or other daily tasks when my eyelids are so inflamed. I guess steroids are the only option until they develop something better. Is Tacrolimus a promising nonsteroidal option?
The treatments of this condition are application of topical corticosteroids (betamethasone, clobatesol, flucinolone) which will reduce the inflammatory process. Topical immunomodulators like pimecrolimus and tacrolimus can be used in severe conditions.
I hope it helps. It is very difficult to precisely confirm a diagnosis without examination and investigations and the answer is based on the medical information provided. For exact diagnosis, you are requested to consult your doctor.
Hormonal contraceptives such as the pill and the patch may increase the blood level of tacrolimus. Tacrolimus may also reduce the effectiveness of these hormonal contraceptives. For this reason women who could get pregnant should ideally use a non-hormonal method of contraception, eg condoms, to prevent pregnancy while taking this medicine. Seek advice from your doctor or pharmacist.
there are prograf assistance programs that the company offers. If this is not feasible than using other cheaper medications such as verapamil for example for HTN for example will alllow much lower doses of prograf to be used (it delays metabolism of the medication) and thus it comes out cheaper.
AS I HAVE SUFFERED BREATHLESSNESS AND WALKING PROBLEMS,I HAVE BEEN TAKEN OFF TACROLIMUS AND PUT ON NEORAL-YET THERE IS NO IMPROVEMENT IN MY CONDITION.IS THERE ANY OTHER ANTI REJECTION DRUG THAT YOU WOULD RECOMMEND (I HAVE HAD A LIVER TRANSPLANT RECENTLY)? IN YOUR EXPERIENCE,CAN MY SITUATION BE IMPROVED?THANKS.
My 7 week old daughter, who was born five weeks premature has been having issues with hyperkalemia. Her pediatrician and the kidney specialist she had been consulting with order more labs and an ekg at our local childrens hospital. Today I got a voicemail saying that the potassium levels had went down, but all the other labs like the cretin check where abnormal and she was waiting to her from the kidney specialist. She also said that her ekg was abnormal.
I have had jello feeling w/panic attack before. It is possible you are having panic attacks, but your doctor should eliminate all known medical causes for your symptoms before relegating you to a psychiatrist.
I also found this for your consideraton on medicine net, a com website:
"Sometimes, patients with hyperkalemia report vague symptoms including:
nausea,
fatigue,
muscle weakness, or
tingling sensations.
i would be extremely cautious about using it until more data is available especially since its purported effects on tacrolimus and cyclosporine metabolism are extreme. i am quite confident that there will be clinical trials coming down the road extremely soon.
My tacrolimus level is 4.2 after 4 months of liver transplant, Is it dangerous? what should i do?
T-wave abnormalities requires further evidence and except for hyperkalemia (electrolyte) the T-wave alone is not a diagnostic of any medical issues. Conditions to be considered with T-waves will usually be abnormal in ventricular hypertrophy, LBBB, chronic pericarditis, and in electrolyte abnormality.
Whether to see a cardiologist would depend on whether you have any supporting symptoms, health history, family history of cardiac disease, etc.
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