She said that very rarely has she seen any dog respond to cyclosporine after not responding to tacrolimus. She also said that because our dog doesn't have a dry, goopy nose, that pilocarpine wouldn't be a first choice. She recommended a mix of tacrolimus with sirolimus. She said sirolimus is new. I have not been able to find anything about this drug on the internet. Also, it's $95! Anyone have any experience with this?
Can tacrolimus eye drops and Cyclosporine ointment cause cancer in dogs? My precious dog, baby and best friend was diagnosed just last week with Transitional Cell Carcinoma in his bladder. It is a rapid growing cancer. I am completely heartbroken and am wondering if there was something I could've done to prevent this. He has been on these two eye medications for about a year. His name is Duke and he is a beautiful tri-colored collie and is a little over 10 years old.
i wouldnt lower the tacrolimus dose further
I assume your dog has keratoconjunctivitis sicca? What treatments have you tried? What medications have you used thus far that have not worked?
The surgery itself isn't terribly risky, or at least no riskier than any other procedure where anesthesia is involved, but it's not a perfect solution either. It's possible for salt crystals from the saliva to form in the eye, causing serious irritation and more problems.
Hello....My dog had dry eye....the vet was originally spinning a serum from a donor dogs blood....It seemed to work great...! Two Bits eyes were clear and full of sparkle....Then the owner of the donor dog, decided not to have the blood drawn from his dog anymore....We couldn't use Two Bits blood, It was a long time ago, and I don't really remember why, but I think it was just because she would not cooperate with the blood draws....eventually she ended up with cyclosporine...
His cretanine is almost 1.4 or around. My question is that should he continue his TACROLIMUS tablets or should switch to some other tablets which are safe for kidneys?
Secondly , in my sorrounding there is an opinion that lowering the TACROLIMUS dose also let the liver enzymes to increase? Do you favour such opinions as my father has lowered his tacrolimus dose to keep his kidneys safe?
Sir ,will wait for your kind reply.
Thanks.
s hard to perform my job or other daily tasks when my eyelids are so inflamed. I guess steroids are the only option until they develop something better. Is Tacrolimus a promising nonsteroidal option?
The treatments of this condition are application of topical corticosteroids (betamethasone, clobatesol, flucinolone) which will reduce the inflammatory process. Topical immunomodulators like pimecrolimus and tacrolimus can be used in severe conditions.
I hope it helps. It is very difficult to precisely confirm a diagnosis without examination and investigations and the answer is based on the medical information provided. For exact diagnosis, you are requested to consult your doctor.
My dog is being treated for dry eyes with Optimmune (cyclorsporin). I apply it twice a day . She has been on this medication for over 2 years and her eyes are not doing or looking any better. She now has a spot on her eye that is cloudy so I have stopped using the medication until I can see Vet. This is the second time she has had a spot come on the eye. I am using the medication the Vet gave me the last time she had the spot on her eye and it is Neomycin and Polymyxin ointment.
can I use flax seed oil for eye drops for my dog? We have tried antibiotics, tacrolimus, and all over the counter drops but nothing seems to help, someone suggest flax seed oil but will only try this if I know it will not harm her in any way.
Hormonal contraceptives such as the pill and the patch may increase the blood level of tacrolimus. Tacrolimus may also reduce the effectiveness of these hormonal contraceptives. For this reason women who could get pregnant should ideally use a non-hormonal method of contraception, eg condoms, to prevent pregnancy while taking this medicine. Seek advice from your doctor or pharmacist.
there are prograf assistance programs that the company offers. If this is not feasible than using other cheaper medications such as verapamil for example for HTN for example will alllow much lower doses of prograf to be used (it delays metabolism of the medication) and thus it comes out cheaper.
AS I HAVE SUFFERED BREATHLESSNESS AND WALKING PROBLEMS,I HAVE BEEN TAKEN OFF TACROLIMUS AND PUT ON NEORAL-YET THERE IS NO IMPROVEMENT IN MY CONDITION.IS THERE ANY OTHER ANTI REJECTION DRUG THAT YOU WOULD RECOMMEND (I HAVE HAD A LIVER TRANSPLANT RECENTLY)? IN YOUR EXPERIENCE,CAN MY SITUATION BE IMPROVED?THANKS.
i would be extremely cautious about using it until more data is available especially since its purported effects on tacrolimus and cyclosporine metabolism are extreme. i am quite confident that there will be clinical trials coming down the road extremely soon.
My tacrolimus level is 4.2 after 4 months of liver transplant, Is it dangerous? what should i do?
Treatment is by topical steroids or oral therapy of corticosteroids in severe cases. Topical creams like tacrolimus ointment (Protopic) and pimecrolimus cream (Elidel) are also useful.
If still the symptoms do not improve then please get a clinical examination done by a dermatologist.
I hope it helps. Take care and please do keep me posted in case you have any additional doubts. Kind regards.
He goes to work with me every day, where he acts as a therapy dog for my (human) patients. He is a cheerful, gentle, playful, friendly dog who easily wins people's hearts. He seems to work especially well with anxious people - his presence calms them.
I hope and pray that he does not have lymphoma or any other cancer. What is the differential diagnosis for a canine mediastinal mass - probably an enlarged lymph node?
Not the right place for this question. Sorry.
I am taking Tacrolimus 3mg, Myfortic 360mg, twice a day. My Creatine is 1.25 and BUN is 29. I am also interested in your opinion.
I was initially taking Tacrolimus and then I was switched to Sirolimus. I cannot remember why my immunosuppressive was changed but Sirolimus was pretty new then and maybe my surgeon wanted to try it and see how I did. I wasn't very fond of it as I recall. It came in small packets and was an oily solution. It's been a while but I do remember that. I probably mentioned this to my surgeon and that could be the reason that he switched me back.
Another Dermatologist thought my immune system caused the reaction and prescribed Tacrolimus ointment...told me to put it on until the color came back. I did that for 3 months and didn't notice any significant change....only occasional peeling of the skin next to the head of my penis! Is there ANYTHING that will fix my skin?
Also use of antibiotic creams, antihistaminics, sun screens and tacrolimus(available by prescription) helps but consultation of a dermatologist is required first. Also it is not permanent and will slowly go away with proper treatment and lifestyle changes.
I sincerely hope it helps. Take care and please do keep me posted in case you have any additional doubts. Kind regards.
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