The PDE5 inhibitors sildenafil, vardenafil and tadalafil are competitive and reversible inhibitors of cGMP hydrolysis by the catalytic side of PDE5.
Although rare, Viagra (sildenafil), Cialis (tadalafil) and Levitra (vardenafil) can cause muscle pain and unusual skin sensations or paresthesia. In clinical studies, Viagra caused muscle pain and paresthesia in less than 2% of patients. Patients who experience these side effects should stop taking the medication and consult their physician. These medications increase blood flow to the penis by inhibiting the enzyme phosphodiesterase type 5 (PDE5).
I tried sildenafil and tadalafil and both worked very well only a few first times - later the was a small or sometimes no response. My testosterone is high (810) and no smoking, not overweight, blood work works O.K.
I'm 56 years old. Any suggestions?
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Hepatotoxicity
Despite fairly extensive use, tadalafil has been linked to only rare reports of serum aminotransferase elevations and clinically apparent liver injury. In a single case report, tadalafil was linked to cholestatic hepatitis arising within a few days of starting the medication. Immunoallergic features and autoantibodies were not present. The injury was self-limiting without residual evidence of bile duct injury.
Hi,
I sincerely feel that you should consult a urologist for the same if the oral medications are not able to treat the ED. I hope you have tadalafil also apart from sildenafil. The next step is usually papaverine injection but needs to be given by an expert only. I sincerely hope that helps. Take care.
m a nurse and had a guy come on our floor with sildenafil as a regular medication. I asked the doctor why and he said the pulmonary hypertension. So I could see a use for what your husband said.
medications such as phosphodiesterase type 5 inhibitors (such as sildenafil [Viagra], tadalafil [Cialis], vardenafil [Levitra]) or penile injections; surgery to correct blockages in the veins that drain the penis; or a penile implant.
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I'm 28. I am capable of getting proper erection any time of the day except for being in bed with a girl. After clinical check and running tests the doctor confirmed that my sex drive is healthy and functioning and that my problem is purely psychological. Performance medications help sometimes help (sildenafil, tadalafil, vardelafil, .. ). But in other times they just don't have any effect.
I AM 63 YRS FIT AND HEALTHY, MARRIED TO LADY 30 YRS. LATELY, I STARTED USING SILDENAFIL, BUT LAST WEEK SOMEONE RECOMMENDED 20MG TAZZLE- TADALAFIL. DOSE SUGGESTED 1-20 MG PER DAY FOR 3 DAYS, AFTERWARDS 1 TAB EVERY 3 DAYS.
SINCE I HAD JUST STARTED FREQUENT 4/5 TIMES URINATION PROBLEM, I WAS ADVISED TO TAKE FINAST 5MG DAILY. I WAS TOLD THIS FINAST DOSE WILL ALSO ADDITIONALLY HELP IN SCALP HAIR GROWTH! I READ ON SITE CIMSASIA.COM THAT FINAST HAS SIDE REACTION OF IMPOTENCE.
If the problem is vascular, as is the case in systemic diseases, corrective measures can include phosphodiesterase inhibitors, such as sildenafil (Viagra), tadalafil (Cialis), etc.). These can be prescribed by your doctor after an evaluation including physical and laboratory exams.
Additionally, men with diabetes can develop varying degrees of hypogonadism which can result in testosterone levels being lower than usual.
Other medications are metformin 500mg twice daily, Lisinopril 40mg(morning), Trazodone 50. Recently I take tadalafil 10mg and my blood sugar goes very low. I also tried 2.5mg daily at night, again my blood sugar goes very low. I wear a freestyle libre patch. What medications are interacts with tadalafil? Is Viagra will be safe for me?
Viagra(Sildenafil) is a vasodilator (that is, a drug that dilates blood vessels), and consequently it lowers the systolic blood pressure (the "top" number in blood pressure measurements) by an average of 8 mmHg. In the majority of patients with heart disease, including most of those being treated with antihypertensive drugs, this is not a problem.
Hi,
You could discuss treatment with drugs in order to improve the condition (there would be sildenafil, tadalafil). There are some men who would need to be on it and then regain function, some may need it longer than others, and then there would also be those who may not adequately respond.
Have there been any problems in the past before the operation? It would be important as the chances of returning to the optimum would also be affected if there was any problem at the start.
Since a doctor needs to prescribe either, then ask your prescribing physician. Don't do online pharmacies for this though as they are often not legit or reliable. Go to a regular pharmacy to get it.
She has had severe gas problems even before she started Sildenafil and currenlty she is taking drokin , flunil and happi which is an antacid there is relief but the pian comes back ...
the pain is majorly in the upper abdomen along with a tight feeling and sometimes in the right side!!
what should i do to help her??
My doctor told me the delayed ejaculation is common with 50 mg dosage of Sildenafil and he said that Sildenafil 25 mg should be adequate and will not lead to delayed ejaculation.
I don't smoke and have no other major health problems. Is it useful to have intercourse 3-4 hours after taking the pill (25 mg), to slightly reduce the effect of the pill on ejaculation ?
Appreciate any advice related to this, thanks in advance !
Hepatic Impairment
In volunteers with hepatic impairment (Child-Pugh Class A and B), sildenafil clearance was reduced, resulting in higher plasma exposure of sildenafil (47% for Cmax and 85% for AUC). The pharmacokinetics of sildenafil in patients with severely impaired hepatic function (Child-Pugh Class C) have not been studied. A starting dose of 25 mg should be considered in patients with any degree of hepatic impairment [see Dosage and Administration (2.5) and Clinical Pharmacology (12.3)].
Side Effects of Penegra?
Like all medications, Penegra (sildenafil) can cause some side effects. These are usually mild & tolerable and don't last longer than a few hours. Some of these side effects are more likely to occur with higher doses of Penegra.
I am 83 and take Sildenafil once a week before breakfast and sex. I usually have an upset stomach for 1-2 hours after. It's the price I pay for sex.
I have now have tried all the usual tablets (Viagra, Levitra, Tadalafil although not Spedra - yet). Tadalafil seems to work best although even that doesn't facilitate an erection sufficient for intercourse. So, looking for alternatives, I discovered alprostadil.
I don't have ED but I was curious if my erections could be stronger. I spoke with my doctor and tried Cialis and Viagra. Since they have much different half-lives, I thought I'd try the following: Taking 10-20 mg Cialis every 2-3 days, then taking 20-40 mg Viagra (generic sildenafil) before sexual activity. My questions isn't whether this is effective - it certainly is. But is there any risk to doing this? I moved so I don't have a doctor right now.
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