Hi, Laura.
I've been on Rebif, 4 and 1/2 months. I started on Copaxone, but after 6 and 1/2 weeks, we found out that my "side effects", were actually a severe allergy to it,
The Rebif auto-ject is easy to use, and has the finest needle. I don't even feel it go in.
And that is saying something, because I am 5'2 and weigh 77#s.
I take an Advil for Migraines 1/2 hour before I inject.
(I didn't get them until I was on it for just over 3 months.