rebif studies

he immediately took me off Rebif for 30 days, and started me on Copaxone. Copaxone has had numerous studies and all the studies proved that Copaxone doesn't increase anxiety. I urge you to let you Dr. know about this as soon as possible, because Rebif continued to make my depression worse even with an increase in my anti-depressant. I was having very unhealthy thoughts and they just continued to get worse. Unfortunately with Copaxone the injections are daily.

Earlier Phase 2 studies showed that treatment with alemtuzumab reduced the accumulation of disability and the frequency of relapses in people with early relapsing-remitting MS, compared to Rebif® (interferon-beta-1a-rebif/index.aspx, interferon beta-1a, EMD Serono, Inc. and Pfizer, Inc.). (New England Journal of Medicine 2008 359;17:30-45) Rebif is a registered trademark of EMD Serono, Inc. and Pfizer, Inc. http://www.nationalmssociety.org/news/news-detail/index.aspx?

Does anyone know if there are any statistics showing the effectiveness of Rebif if used only twice a week versus three times a week? My husband will be losing his job come the end of August, and along with that, our benefits. I figure if I start now going to only 2 times a week, between now and the end of August I can make my Rebif last for at least another month. I know this is not the best thing to do, but it appears to possibly be the only solution.

The Comparison of Alemtuzumab and Rebif® Efficacy in Multiple Sclerosis (CARE-MSSM) I and II studies are designed to determine the safety and effectiveness of the investigational drug alemtuzumab as compared to the FDA-approved therapy Rebif (interferon beta-1a), in adults with relapsing-remitting multiple sclerosis (RRMS). The studies will look for differences between these drugs on the progression of disability and in the number of relapses (flare-ups) and brain lesions caused by MS.

When I was dx'ed last fall my neuro gave me info on 3 studies: Rebif New Formulation vs placebo; efficacy of combining Avonex and Copaxone; and a natural history study, as an adjunct to the Avonex/Copaxone study. I declined all of them as I live about 450 kms from the research facility and being in a study involves monthly follow ups. Winter was around the corner, I was overwhelmed by my dx, and did not want to make a commitment to be doing all that travel.

Copaxone is the weakest and he did not recommend it for me. Betaseron, Rebif and Avonex are essentially the same drug, Intefereon beta, administered in different doses. My Neuro is a big believer in Neutralizing antibodies. Avonex NAB rate is around 5% Rebif around 10-15% Betaseron 25-30% NABs can bind to the active side of the interferon molecule rendering it useless. So naturally (if you believe in NABs) you would likely pick the one with the lowest NABs.

He had so much more knowledge and was worth every penny. He told me that Rebif only stays in the system for half an hour but the benefits from it last a month or more. He said i dont have to wean myself off and that i can stop taking it right away. I just need to get a chicken pox vaccination in the next week as i have no immunity and it is very dangerous to catch while pregnant. After that i can start trying for a baby woohoo!

I am going to challenge the Rebif, as I believe in what the studies say about it prolonging disability. I did have shaky legs while on the Rebif, but thought it was do to the MS. I really won't know until I try it again though. Now that I've had this break, I think I will recognize what is causing what. Because I started those meds shortly after being diagnosed, I really have no baseline of comparision.

Hi, I was so happy to read the news but, I'm currently on Rebif, so I don't see a reason to switch, only thing is no injecting..... And rebif does not have the hair loss, and fatal liver damage warning ....

Some of you may recall my post in the last week or so regarding my recent neuro appt and my problems with Rebif and liver enzymes. I sought your advice on Novantrone, as my neuro had stated that this would be the next course of action, if Rebif is unsuccessful for me after a further period of labs and re-introduction to the med.

Copaxone, Rebif and I believe Betaseron are all injected subcutaneously (just below the skin), so your size and weight is irrelevant. Avonex is injected intramuscular about an inch and half deep. Surely your thighs can accomodate that. You should be taking one of these if your definite RR MS.

This is a question for any of you who are or have been on any of the interferons. Last evening I had a bit of a meltdown, a crying jag that lasted about an hour, and a really DEEP feeling of sadness. Not quite despair, but close. I felt a bit overwhelmed with everything: my double vision coming on six months now; being off work; feeling isolated; exhausted; annoyed at my 20 lb weight gain since my dx; not being able to make vacation plans, etc. etc.

I have been given 5 studies to choose from. They are all different and Im feeling a little overwhelmed. How should I choose? What questions should I ask?

Is anyone here familiar with the somewhat recent studies that demonstrate copaxone significantly reduces brain atrophy and tissue loss, not to mention a reduction in theconversion of inflammatory lesions into black holes(possibly better repair)? What does/would this mean for cognitive dysfunction (concentration, learning, recall, memory)? Would this influence your choice of DMD?

I have MS and have been taking Rebif foe 7 years. It has worked very well. I just learned that my current drug insurance plan from Humana will not cover Rebif in 2015. What plans cover at least some of the Rebif cost? My copay with Humana was about $300 per month. Would like not to exceed this amount.

Yes, I am on rebif for 11 months and must take advil liquid gels To stave off headache fever that wakes me up!

They still use disease modifying drugs for PPMS. There are less people for PPMS studies so its hard to compare them to RRMS studies. People are not statistics. I have a form of cancer which does not respond to chemo. Guess what chemo worked in my case. He is thinking Tysabri to be more aggressive. I have PPMS and I would do Tysabri if I did not have Cancer.

So the ins company wont pay for Copaxone or Gilynia until my daughter first tries Rebif (i guess because its cheaper for them.) I have a concern with her being on an interferon due to the possible mental health side effects. She is already on Lexapro for anxiety and mild depression. I dont want anything adding to the issue. We have dr app tomorrow to discuss Rebif but I dont want her on it. Anyone have bad side effects with Rebif??? Any advise for me?? Thank you.

Hello. Does anyone take Rebif for MS? Is it helping? How long before any improvement? Does anyone think that it's just a false hope with nasty side effects? Thanks.

I have been on Rebif for four months now, and I am not going to do another shot, I can't handle the side effects. I've tried premedicating and nothing seems to work. How many of you are in the same situation? and what did you do?

I took my first shot of Rebif today. I gave myself the shot and i thought this is great no stinging, no redness, no lump like i had with Copaxone. Then WHAM!!!! I had abdominal pain about an hour after the shot it lasted for about 6hrs The only thing i could compare it to was a 6hr nonstop labor pain. We will see what happens Monday when i take the next shot. Does anyone else get this abdominal pain on Rebif.

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