Hi Corrie,
We have alot of discussion on our forum regarding varied experiences with the DMDs. I always suggest looking at your lifestyle and seeing what is a good fit for you. For example, look at the scheduling of dosing (Rebif 3x's weekly, Avonex 1x weekly, betaseron 4x's weekly and copax, once daily).
Also, there are three orals - I would have to look up the dosing, but believe them to all be daily.
My experience is with Rebif. Very tolerable, with a super thin needle.