Blood levels of cyclosporine are increased if taken with grapefruit juice. A plausible mechanism involves the combined inhibition of enteric CYP3A4 and P-glycoprotein, which potentially leads to serious adverse events (e.g., nephrotoxicity).Blood levels of tacrolimus (Prograf) can also be equally affected for the same reason as with cyclosporine.
I believe that diarrhea can cause an elevation in Prograf level. Taking Prograf with food can decrease absorption and result in a lower Prograf level. This is even more pronounced if you take it with fatty food. If Prograf doesn't upset your stomach it is best taken about 1 hour before eating - on an empty stomach.
The range on my labs sheet is 4 - 16 so you are well within range.
I am not physically restricted - I walk 1 mile or more day and do 10 minutes of other light exercises most days. My BP runs under 120/80 most of the time. I understand carvedilol helps prevent stiffening of the heart muscle and can help restore LV function to some degree. How specially, so it do this? What is the biochemical mechanism?
I have been getting a very unwell feeling after i eat since i got home frome hospital. Its kind of the same feeling i had after my transplant when i was on hi doses of prograf. Any ideas ? Can i try lowering my prograf to try and alievaite this cognitive impairment by adding maybe some cellcept? I have never been on anything but prograf alone except prednisone 6 mo tx .
What does your doctor think? I wouldn't dream of fooling around with my immunosuppressive regimen unless a doctor I really respected strongly advocated adding narigenin into the mix. I cleared while on Prograf and I was genotype 1b. I haven't read anything definitive about the impact of tacrolimus on treatment outcome in the transplant population.
I had a bad reaction from eating these foods. I had been warned about grapefruit juice, as it increases the amount of Prograf in the blood-stream. I did not know about the problems with other foods. Being a health food addict, this is what I eat. I had noticed I had not felt good for a couple of days but did not think that much about it. After about 3 days I knew something wasn't right with my body.
Almost 4 months post transplant and have been experiencing a dull headache for the last few weeks, everyday. It is a dull headache and the discomfort is random...sometimes its on the left side of the head, sometimes on the right, sometimes between the eyes, etc. It's not a migraine, but a dull pain, nagging pain. Can this be a side effect from any of the medications? Pentamidine (aerosol) 1x monthly, Prograf 2mg 2x daily, metroprolol tartarate 12.
The mechanism of action of Campral® (acamprosate calcium) Delayed-Release Tablets in maintenance of alcohol abstinence is not completely understood. Originally, several neurotransmitter systems, including GABA, were investigated for a possible role in Campral's mechanism of action. However, recent evidence suggests Campral's main interaction is with the glutamate system. Chronic alcohol exposure is hypothesized to alter the normal balance between neuronal excitation and inhibition.
http://www.nasdaq.
The intent is to convert me to 100% Rapamune because of the nephro-toxicity of the Prograf and my young age and because of the anti-cancer properties of Rapamune. Data, while horribly limited, has shown Rapamune's anti-cancer properties have had success against vascular tumors such as mine so EHE, in this case chronic, is part of the cancers Rapamune affects (some cancers it has no effect).
I went into rejection twice in the hospital and because of this my transplant team saw it best to put me on 5mg of prograf twice a day as well as 4 mg of rapimune, which by the way was off label and i had to sign a release form for. Just within the past 2 months they lowerd my dosage of rapimune to 2mg but kept the prograf the same. My question to you is exactly how suppressed is my immune system?
I inherited some of my aunts pierced earrings, she had Hepatitis C. Will soaking them in alcohol kill all the germs from her illness? How long should I soak them?
My history: liver transplant 1 year ago, had 2 moderate rejections and 1 mild since transplant. At present time having moderate rejection, recently had one portal stent and 8 Bilary ERCP's to remove stones and sludge and had stenting done, and at the present time there are no blockages. Was on Rapamune (5mg a day) prior to hernia surgery and then week before hernia surgery was put on Prograf (4mg a day) and taken off the Rapamune. I have been on Progaf since hernia surgery (8 weeks ago).
Plavix has a unique mechanism of action by blocking the amplification of platelet activation by released ADP, and often used with aspirin to prevent the risk of clots for the first year after DES implant. Plavix and aspirin have different mechanism of action to prevent clots. After a year, plavix is usually discontinue as the risk for clots is decreased, and aspirin is continued long term. The risk of a clot is about 3%.
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