pegylated interferon alfa 2b peg intron

a pilot study. (nonstatistically significant differences) http://www.ncbi.nlm.nih.

The treatment with most promising results is a combination of pegylated interferon alfa (Pegasys, PEG-Intron) and the antiviral drug, ribavirin. Interferon alfa is a protein which the human body produces naturally as a defense response to viral infections. Pegylation describes a chemical process that makes the interferon last longer in the body. Interferon increases the potency of ribavirin in the treatment of HCV.

Pegylated interferon plus ribavirin compared with interferon plus ribavirin increased the proportion of patients with sustained virological response, but at the cost of more adverse events." http://www.medscape.com/viewarticle/557838 (Free Mescape Registration Required) ---------- Also, re another topic -- frequent VL testing, some interesting comments by "Susie" re a well-known clinician/researcher.

As a result of its controlled-release mechanism, Locteron was dosed half as frequently as PEG-Intron. PEG-Intron is one of two currently marketed pegylated interferon products for the treatment of hepatitis C, a market that currently exceeds $2.5 billion in worldwide sales. Additional results from SELECT-2 demonstrated the substantial tolerability advantages of Locteron.

Pegasys uses a branched PEG molecule to bond to its IFN alpha (2a) which keeps it in your system slightly longer than Peg-Intron which uses a non-branched PEG molecule on its IFN alpha (2b). The two pegylated interferons seem to work equaly well Or something like that.

I've taken both 2a & 2b. For me, 2a had less side effects. I've been told that 2a has a smaller peg than 2b and that's why it has less side effects. I'm not a chemist so I can't confirm that information. Just know that 2a was better for me.

"PEG-interferon alpha is a pegylated interferon composed of 165 amino acids. The PEG (polyethylene glycol) protects the molecule from proteolytic breakdown and increases the biological half-life of the interferon protein" http://en.wikipedia.org/wiki/Peginterferon_alfa-2b " In Pegasys, a large, branched, mobile PEG is attached to the interferon alfa-2a molecule, providing a selectively protective barrier against rapid absorption, metabolism and elimination" http://www.

The products in question are Temodar (temozolomide) for brain cancer and hepatitis C and cancer drugs PegIntron (pegylated interferon alfa-2b) and Intron A (interferon alfa-2b), according to Merck's just-published quarterly report. All three of the drugs were acquired when Merck bought Schering-Plough in 2009.

As reported in the August 2008 issue of Hepatology, Stephen Zeuzem and an international team of colleagues conducted an open-label Phase 2 study in which 458 treatment-naive patients with genotype 1 chronic hepatitis C were randomly assigned to receive either standard therapy with 180 mcg once-weekly pegylated interferon alfa-2a (Pegasys) or else albumin interferon alfa-2b at doses of 900 or 1200 mcg once every 2 weeks or 1200 mcg once every 4 weeks for 48 weeks.

The two SOC (standard of care) drugs used to treat Hepatitis C are PEGASYS (Peginterferon alfa-2a) and Peg Intron (pegylated interferon alfa-2b).

In a Phase 2b study with pegylated interferon and ribavirin, Pharmasset's PSI-7977 had a 100 percent success rate against Hepatitis C genotypes 2 and 3.

“Medtronic, a Minneapolis-based drug device company, recently announced that it has started a clinical trial to evaluate a pump that delivers a continuous infusion of interferon alfa-2b (Intron A) for the treatment of hepatitis C virus (HCV) infection. The trial will test the same type of pump used for continuous insulin delivery for people with type 1 diabetes.

Michael Volk, MD, University of Michigan, Ann Arbor, Michigan, and colleagues obtained data of new patient prescriptions for pegylated interferon alfa-2a and -2b (Pegasys and Peg Intron, respectively) filled between 2002 to 2007. Results of the prescription audit showed there were 126,000 new prescriptions for pegylated interferon products in 2002 and by 2007 that figured declined to 83,000 prescriptions. Researchers project fewer than 1.

I finished treatment with Peg-Intron and Ribavirin in 2007, after a 24 week course. I acheived non-detectable levels of HCVRNA after 4 weeks of treatment. I have, however, since relapsed. My current doctor would like to retreat with Infergen and Ribavirin, with the belief that the HCV virus has developed some form of immunity to the pegylated interferon.

The study, called COPILOT (COlchicine versus Peg-Intron LOng-Term), showed that low-dose peginterferon alfa-2b was superior to colchicine in improving the disease-free survival of patients with cirrhosis and portal hypertension, especially in patients who stayed on treatment.

Hi, if the viral load is greater than 20,000 IU/mL and HBeAg is negative then Interferon-alfa (Roferon A, Intron A), pegylated interferon-alfa (Pegasys, Peg-Intron), lamivudine (Epivir-HBV), adefovir (Hepsera), entecavir (Baraclude), tenofovir (Viread) or telbivudine (Tyzeka) may be used as initial therapy. There are standard protocols for therapy of hepatitis B infections, so you can clarify your doubts with your treating doctor. Regards.

Two kinds of pegylated interferons are available -- peginterferon alfa-2a (also called alfa-2a) and peginterferon alfa-2b (also called alfa-2b). The main difference between these two pegylated interferons is in the dosing. Alfa-2a is used as a fixed weekly dose. Alfa-2b is used as a weekly dose based on the weight of the patient. There are other differences between the two drugs, but they are mostly technical and are used by the prescribing physician.

About 30% of all the drugs we take are metabolized by the CYP 3a, and so are the Protease inhibitors. The interferon is an inhibitor also (in fact, the reason many hepatitis patients need stronger doses prior to and during tx, of many meds is because of natural interferon, (any viral infection raises interferon levels,) inhibiting the way all drugs are then metabolized. The Interferon making the system more sluggish as it concerns other activities.

Ribavirin combined with interferon alfa-2b, interferon alfacon-1 (Infergen), pegylated interferon alfa-2b, or pegylated interferon alpha-2a, all are approved for the treatment of chronic hepatitis C. Interferon beta-1b (Betaseron) and interferon beta-1a (Avonex) are approved for the treatment of multiple sclerosis. Interferon alfa-n3 (Alferon-N) is approved for the treatment of genital and perianal warts caused by human papillomavirus (HPV).

Pegylated interferon alfa 2b peg intron

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