I have taken antihistamin(first,second generation H1 blocker, also H2 blocker), mast cell cell stabilizer(monokast) which are not responding to the hives . I have started taking glucocorticoid(prednisolone, deflacort) which are doing good. I have not found any trigger for this hives, which appear everyday and go away after taking steroid.
I have been sick for the past 2 years. I have been diagnosed with POTS, but also had other symptoms that my POTS drs didn't feel was related. After extensive testing, I went to Brigham and Women's in Boston to see Mast Cell drs and have been diagnosed with mast cell activation disorder. I too am on treatment for it now. It has not exacerbated my POTS if anything it has made me feel a bit better. I am not great, but definitely better then when this whole thing started.
The beginning treatment as described by Afrin and other doctors in their talks is an H1 blocker, an H2 blocker and a mast cell stabilizer such as quercetin (which helps to keep the mast cells from getting set off too easily).
Hello, I am sorry to hear about this and glad to help.
First get a copy of the biopsy reports, review each report carefully to see whether or not it indicates that each mast cell tumor was"completely" removed and that the "margins" are clean. If not, the few mast cells left simply regrow and form another tumor.
Review your dogs diet carefully and consider the anti-cancer diet.
something like prostaglandin induce mast cell tissue，it is called Mast cell tissue hyperplasia medically.The mast cell tissue release Histamine which spread to the air by some ways which cause allergic phen—.And I think the mast cell tissue is highly related to brown adipose tissu.Brown adipose is distributed in scapula,shoulder,neck, perineumIt.So,you might feel burning and scratch frequently in these place.Generally,I thought the instinct of PATM caused by histamine is immune system problem.
It was biopsied and according to the pathology report the microscoping findings say that it was a Mast Cell Tumor, Low Grade 2. The vet suggested blood work every 6 months and x-rays once a year because she might get a tumor on her organs, said that her mitotic index is a 1 and that survival would be up to 70 months. If she were to get another mass he would do surgery again but that it would most likely come back.
The doc suspects my dog has a Mast Cell Tumor. This would mean the tumor would be taken out, including a large margin around the area. Depending on what the Tumor tests out, it could mean following up with another operation to get more of the margin area out, and chemo and radiation therapy.
I just do not want to put my dog through any operation. What happens if I let this go and do nothing? My dog is eating, playful and in no way seems to be in pain.
If the molecules on the surface of a mast cell bind to their specific antigen they stimulate the mast cell to release several chemical messengers. The normal purpose of these chemicals is to organise a more effective immune response, but in sufficient quantities they can produce the damaging symptoms of allergy. The Antigen that causes such a reaction is known as an allergen.'
http://www.barefoot-botanicals.com/allergy-testing.asp
Hope it helps.
Take care and regards.
bone marrow, gastrointestinal, heart, pulmonary, and central nervous systems may be involved directly, via mast cell infiltration, or indirectly, via mast cell mediator release.
The major criterion for diagnosis is multiple dense infiltrates of mast cells observed in bone marrow biopsy specimens and mast cells stained for tryptase in biopsy specimens from other organs including her skeletal tissue.
Treatment consists of a period of no lens wear, a combination anti-histamine and mast cell stabilizer eye drop, and possibly changing to gas permeable or daily disposable soft lenses.
I ran across this forum while searching for information on Mast Cell Activation Syndrome with P.O.T.S. (positional orthostatic tachycardic syndrome).
I have a suggestion. Some of you might want to try taking an H1 and H2 histamine blocker an hour before eating and see if that does any good. Benadryl is an example of an H1 and Pepcid is an H2, both available over the counter. Benadryl will knock you out if you aren't used to taking it. Zyrtec might be a better choice for an H1.
I get stringy mucous in my eyes.My doctor gave me patanol but it only worked for 6 days.It has only .01 strenght.Would a stronger strenght relieve my eye symptoms?
I wonder are you hypothyroid? Whenever i am on T4 only thyroid hormone, like synthroid, levothyroxine (the usuals that docs prescribe), I can have bad sweats/hot flashes. I don't do a real good job of converting T4 to ,T3 (removing 1 iodine molecule). I use a med with some of both.
For a while I still had some residual night sweats. My doc sold me s bottle of Pharma brand GABA, a neurotransmitter that can be low in fibro. That did the trick.
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