Norvasc grapefruit interaction
Common Questions and Answers about Norvasc grapefruit interaction
norvasc
A list of medications that have been shown, in clinical studies, to have an interaction with grapefruit juice can be found in the table below. All of the medications, except for theophylline and itraconazole, are known to be substrates of CYP3A. When given with grapefruit juice in pharmacokinetic studies their availability increases. In most cases, the clinical consequence of the pharmacokinetic interaction has not been evaluated.
i just looked on drugs.com on their interactions checker and between the two there were no interactions found, However, there are interactions with other medications. You should look at that site, it gives a lot of good information about all kinds of medication, like your second medication Norvasc shouldn't be taken with grapefruit. Hope that helps.
thanks
Research about the interaction of grapefruit juice with drugs suggests that compounds in grapefruit juice, called furanocoumarins (for example, bergamottin), may be responsible for the effects of grapefruit juice. Researchers believe that furanocoumarins block the enzymes in the intestines that normally break down many drugs. One glass of grapefruit juice could elicit the maximum blocking effect, and the effect may persist for longer than 24 hours.
I like to drink grapefruit juice but hear that it can interfere with some prescription medications. Is that true?
Answers from Katherine Zeratsky, R.D., L.D.
Yes. Grapefruit and certain other citrus fruits and products can interfere with several kinds of prescription medications.
Don't take these interactions lightly. Some can cause potentially dangerous health problems.
Has anyone had problems with Zoloft side effects as a result of eating grapefruits? I started taking zoloft (100 mg daily) just two months ago and have not gotten over what I thought were the initial symptoms--dizziness, drowsiness, itchy skin. I was so tired all day long that I found I had to drink up to 7 cups of coffee a day to stay awake. While reading an old magazine, one title jumped out at me, "Grapefruit Concern".
This, initially the drug does not completely metabolize and has an extended half-life. This why it is dangerous to take grapefruit juice with certain medications. Follow me on this. You take a substance that reduces the production of these enzymes (say grapefruit juice) and for the first four hours the drug does not fully metabolize. After six hours the grapefruit juice wears off, the liver again starts producing these enzymes, and you take a second dose of the medication.
No interaction between both drugs. Note that some aliments like citrus, grapefruit extract can increase the potency of some drugs which is considered an interaction.
i need to know that, what is the interaction between juices of Grapefruit and Hepatitis C? is there any reactions of Grapefruit juice being taken by Hepatitis C patient?
The interaction caused by grapefruit compounds lasts for up to 24 hours and its effect is the greatest when the juice is ingested with the drug or up to 4 hours before the drug. [10]
It is demonstrated for the first time that lemon juice significantly inhibits by 60 ± 3% the CYP3A4-mediated oxidation
http://cat.inist.fr/?
There is an interaction between grapefruit and almost every medication known to man. When it come a to mental health medications grapefruit is a very serious danger. I am glad you are ok and have patience because things will go back to as they were. Grapefruit and st. Johns wort are to things to completelt avoid while taking zoloft and/ or other mood balancing/ altering medicines.
//www.drugs.com/prograf.
I've been taking amplodipine / norvasc 10 mg (antihypertensive) for about a year and a half now and montelukast / singulair 10 mg (leukotriene modifier) for shorter periods (2 months, march - may 2008 and 2 months this year, started in early may and still on it). Last month, after having been on fluoxetine / prozac for about 1 year, I showed some deterioration (more depressive symptoms, more anxiety / panic attacks).
Naringenin interferes with drugs, so you should not take it while on treatment. If you google Naringenin drug interaction or grapefruit drug interaction, you will find a lot of info on the subject.
* Anthelmintics (Used for treating certain parasitic infections, includes praziquantel albendazole and mebendazole)
* carbamazepine (Tegretol) Grapefruit or grapefruit juice slows the breakdown of this drug, increasing the level of it in blood
* Loperamide (Imodium), the anti-diarrhea drug
* colchicine (Colcrys)
The CYP3A4 isoform of cytochrome P450 is located in both the liver and the enterocytes. Many oral drugs undergo first-pass (presystemic) metabolism by the enzyme.
Thanks, Rocker, for posting all that. I was curious about the grapefruit-drug interaction, but had not done the research. I was told to avoid grapefruit during tx. Is that a standard of tx, to avoid grapefruit, I mean, is everyone told that by their caregivers? Just curious.
One thought, did you take anything that may have had a poor interaction with your simvistatin? Grapefruit for example is something that needs to be avoided while taking statins. Grapefruit contains the compound bergamottin, which interacts with certain enzyme systems in the body, such as cytochrome P-450 and P-glycoprotein. These enzyme systems are responsible for breaking down statins, as well as other drugs, into more usable chemicals and transporting them in the body.
I believe fruit juices are problems for many medications, including cholesterol limiting drugs, I recall grapefruit being specifically singled out. For this reason I would never use a fruit juice to "wash down" my medications - I'd not even have juice for a couple of hours after taking medications.
My "tachy" is due to atrial fibrillation and I take both BB and CCB to lower my HR. I have stopped drinking fruit juice all together.
they put my on antibiotics and viccodine ..this morning i felt better and at 12noon took my norvasc 5mg pill then around 5pm i stared felling clammy and hot and noticed my breathing was wierd..then when i went to the train to get a transit card my heart was beating outta my chest just for walking up the train station stairs...when i got home my bp was 143 over 100 and my heart rate was 104...
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