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Nitroglycerin tolerance

Common Questions and Answers about Nitroglycerin tolerance

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Avatar m tn I only take isosorbide prior to a workout, and nitro when engaged in an activity that brings on angina. I understand your doctors are suggesting taking isosorbide daily as aschemia does not always produce angina even though the heart cells are not getting sufficient blood supply. This can lead to a silent heart attack so the medication is recommended continuously whether there is angina or not and older people in general are likely to have a silent heart attack.
Avatar f tn If you miss a dose of Nitroglycerin Patch, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once. When used for long periods of time without a break, some people develop a physical need to continue taking Nitroglycerin Patch. This is known as physical DEPENDENCE. Do not suddenly stop taking Nitroglycerin Patch without your doctor's approval.
Avatar n tn ed is correct nitro dilates vessels. I take a nitrate (isosorbide) for more than 6 years 3 times before going to gym for workout. My blood pressure does not drop between intervals...in fact I was told to have intervals of nitrate free period. It is true, nitro dilates the coronary vessels and prevents angina (chest pain). The patch should only be worn for up to 12 to 14 hours a day, or as directed by your doctor, but continued use with no interruptions can cause a tolerance for drug....
712042 tn?1254569209 Despite clear benefits when given acutely, the organic nitrates rapidly lose their hemodynamic and clinical effectiveness when used as sustained therapy, a phenomenon known as nitrate tolerance. The mechanism of nitrate tolerance has been the subject of numerous investigations and much debate.
Avatar m tn I also have the fast acting nitro pill available but seldom used. That works for me. Have you tried a nitrate? There is a tolerance issue with a nitrate and it is recommended to interupt occasionally for a day or two. For some insight: Different nitrate preparations are often combined. Pills, patches, or paste may be used together with sublingual nitroglycerin to give maximum relief and prevent angina.
572651 tn?1530999357 I have nitroquik - sublingual nitroglycerin - to take if I have angina pains - this morning about 5 am I was miserable and couldn't tell if it was heart or ms symptoms and I took one. As always it stopped my discomfort, depressed my already low blood pressure and I went to sleep for about 3 hours. I've used nitroquik for the past 3 months or so and it always stops the pain and gives me relief within minutes.
Avatar m tn I'm a Raynaud's Phenomen patients who has the CREST syndrome and i use the nitroglycerin patches to control my raynaud's. Can you tell me if the patches used in this way would cause your acid reflux to be worse. When i took the lowest dose of nitroglycerin patches 0.1 didn't notice any but had to move up and now i do. Will this be something that my body may take an adjustment period for before i notice a different of not having symptoms again?
712042 tn?1254569209 Well, it is a real phenomenon which is caused by the body's metabolism of NTG and nitric oxide. What happens after prolonged exposure to nitgolycerin, the nitric oxide which is what nitroglycerin acts through gets to a certain degree depleted. This has been proven by measuring exhaled nitric oxide levels in the air that humans breathe out. At that point, the effect of NTG is attenuated.
Avatar n tn I still had stable angina every time I did some for of cardio activity or is I ate something with sodium. I started using Nitroglycerin patches and even have the pills just in case my angina episode occurs. I had a date and I read online that you can't take viagra and any nitrates cause it can drop your blood pressure really low. So I stopped using my nitroglycerin for about 48 hours so I can take the Viagra.
1098952 tn?1270309713 If a person with HCM were to take nitroglycerin, the symptoms would worsen and the nitroglycerin could even cause a catastrophic deterioration in the person's condition".
Avatar n tn Al, you might want to talk to the doc about using some anti-spasm meds, specific calcium channel blockers or nitroglycerin. They may be of help. The problem is if you really are experiencing SOD after removal of your gallbladder, the only way to handle the situation may be to go through an ERCP with manometry and measure the pressures in the common bile duct. If the pressures are raised, then the typical solution is to cut the muscular opening - the sphincter - at the duodenum.
Avatar m tn The pain lasts anywhere from a few minutes to several hours. I have been prescribed nitroglycerin to take as needed for chest pain and this medicine surely helps. I've had several EKGs and cardiac enzymes done which were all normal. I also had a threadmill/stress test done which was normal. My cardiologist thinks the the probability of me having an occluded/blocked coronary artery is very low.
Avatar n tn The doctor said the left heart was okay but found a narrowing in the right heart which caused coronary spasms during the test. IV nitroglycerin during the test stopped the spasms and dilated the vessel. He did not mention any other problems and recommended sublingual nitroglycerin to treat the spasms as they occur.
Avatar f tn I've never heard of nitroglycerin being used to treat migraine, but glad that it worked. But if it keeps on, and sorry to tell you this, but you probably should see a doctor ASAP. It could be the sign of a coming stroke, since it is sudden and very painful. I started with a sudden very different migraine than any I had ever had before. It turned out that within 3 weeks, longer than usual as a gap in time, I had a full carotid artery dissection stroke.
Avatar m tn The same with his recent heart catherization was chest pressure. In the ER he was given 2 nitroglycerin, 5 minutes apart, the chest pressure went away after the 2nd nitroglycerin. Does any good specialist in cardiology think that my husband should have the open heart surgery for bypasses considering the risks regarding his age, his diabetes? I would appreciate very explanatory answers, easy to understand, what to do in my husband's situation. Thankyou.
Avatar n tn I assume the diagnosis of hyperreactive responses not only to the constrictor effects of acetylcholine, but also the dilator effects of nitroglycerin were detected diffusely in the epicardial coronary arteries of patients with coronary spastic angina. The goal of treatment is to control chest pain and to prevent heart attack. The pain is relieved by a medicine called nitroglycerin (dilates coronary vessels). You have been prescribed norvasc and that should relieve any chest pains.
Avatar n tn My 54 year old "healthy" husband received a stent yesterday due to a 99% LAD blockage! He is the typical type A personality and this only adds to his already stress overload. I realize we are lucky he is still here and thankful for medical technology. I am just concerned that this will forever be a constant worry for him. Any suggestions of how I can help him. Also I asked his MD about having nitroglycerin to have on hand and he said that this wasn't necessary???
Avatar n tn Monotrate, Vasotrate, Ismo, Imdur, Angicor), Isosorbide dinitrate (brand names: Sorbitrate, Isordil), Sublingual nitroglycerin tablets or spray (Angised, Angispan, GTN spray), Transdermal nitroglycerin patches or ointments (brand names: Top nitro, Nitroderm TTS, Myovin). Nitrates are also found in illicit drugs such as amyl nitrate (poppers). If you are not sure if any of your medicines contain nitrates, or if you do not understand what nitrates are ask you doctor or pharmacist.
Avatar m tn I have been on MS Contin,and Percocet for about 3 years,and over that time I have gotten increases to where I am now which is 300MGs MS Contin and 60MGs percocet.My question is,if I take my meds as directed can I keep my tolerance where it is?Or is there a way to keep it from going up?Maybe taking a little less once in a while? I don't want to go any higher on the dosage,what I am on now makes certain activities difficult as it is.Thanks for any help.
Avatar f tn At least once a year we lose control and have to stop because of the tolerance increase. 10 days ago we both stopped taking between 4-5 40mg OC per day. Kratom is the easiest way to stop, and people in other countries have used it for centuries. It's legal, and it works, and it's the Creators gift to heroine addicts. Look it up on U-Tube. Tastes like mud but it makes you feel normal without any withdrawal symptoms. I gotta go so good luck bro, may Yahweh be with you.
Avatar f tn This past weekend we were discussing (not arguing) and the topic of tolerance came up. I said that these pills should never have been given for long term pain management because there is no way to help with the tolerance and the constant need to have more to achieve the same level of pain management. He says that is NOT true. He believes that if it is truly only being used for pain and not for ANY kind of high then you dont build up a tolerance.
Avatar f tn Ive been on pain meds for 5 or so years, and am curious if anyone else who has taken them for that long, has experienced them 'not working' anymore? we build our tolerance, and eventually its not the same. does that mean its time to stop taking them b/c they arent working like they used to? or wein down to get tolerance lower? does this get to a point where regardless of how hight the dosage, there comes a point where they stop working all together?
Avatar n tn You should talk to your doctor as you may be a good candidate for a low dose nitroglycerin patch which opens the coronary vessels to increase oxygen supply to the heart. How are you currently managing your COPD? What medications and inhalers are you using? are you on home O2?
Avatar m tn The doctors just did an ECG and say all is good. Is this possible? She is on constant Nitroglycerin and Morphine prn. Should she get a second opinion? What other procedures could she have done to take away this pain? She says the pain is getting more frequent and stronger. Thank you for your responses.